Efficient synthesis of esters through oxone- catalyzed dehydrogenation of carboxylic acids and alcohols

Since esters are important organic synthesis intermediates, an environmentally friendly oxone catalyzed-esterification of carboxylic acids with alcohols has been developed. A series of carboxylic acid esters are obtained in high yield. This strategy requires mild reaction conditions, providing an at...

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Published inOrganic & biomolecular chemistry Vol. 16; no. 48; pp. 9472 - 9476
Main Authors Hou, Fei, Wang, Xi-Cun, Quan, Zheng-Jun
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 12.12.2018
Royal Society of Chemistry
Subjects
Alcohol
Alcohols
Carbonyls
Carboxylic acids
Chemical compounds
Chemical synthesis
Chemistry
Chemistry, Organic
Dehydrogenation
Drugs
Esterification
Esters
Intermediates
Physical Sciences
Prodrugs
Science & Technology
Substrates
SELECTIVE OXIDATION
MILD CONDITIONS
CONVERSION
AMIDATION
CONDENSATION
ALDEHYDES
OXIDATIVE ESTERIFICATION
WATER-TOLERANT
BULKY DIARYLAMMONIUM ARENESULFONATES
TRANSESTERIFICATION
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Summary:Since esters are important organic synthesis intermediates, an environmentally friendly oxone catalyzed-esterification of carboxylic acids with alcohols has been developed. A series of carboxylic acid esters are obtained in high yield. This strategy requires mild reaction conditions, providing an attractive alternative for the construction of valuable carbonyl esters. Electron-rich and electron-deficient groups are compatible with the standard conditions and a variety of substrates are demonstrated. Moreover, the reaction could easily be adapted to typical prodrugs, drugs and gram-scale synthesis.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1477-0520
1477-0539
DOI:10.1039/c8ob02539h