A tumor-targeting Ru/polysaccharide/protein supramolecular assembly with high photodynamic therapy ability

Supramolecular assembly with tumor-targeting properties or photodynamic therapy (PDT) ability has recently become a focus of interest in biomaterial field because of its high therapeutic efficacy against tumor cells. Herein, we reported a new type of targeted supramolecular nanoparticles for photody...

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Published inChemical communications (Cambridge, England) Vol. 55; no. 21; pp. 3148 - 3151
Main Authors Fu, Hong-Guang, Chen, Yong, Yu, Qilin, Liu, Yu
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 07.03.2019
Subjects
Absorption spectra
Assembly
Biocompatibility
Biomedical materials
Cyclodextrins
Image transmission
Nanoparticles
Photodynamic therapy
Polysaccharides
Proteins
Ruthenium compounds
Toxicity
Transferrin
Transmission electron microscopy
Tumors
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Summary:Supramolecular assembly with tumor-targeting properties or photodynamic therapy (PDT) ability has recently become a focus of interest in biomaterial field because of its high therapeutic efficacy against tumor cells. Herein, we reported a new type of targeted supramolecular nanoparticles for photodynamic therapy of tumor cells constructed using adamantane-functionalized transferrin protein (Ad-TRF) and a β-cyclodextrin-functionalized ruthenium complex (Ru-HOP-CD), wherein Ad-TRFs acted as the targeted sites for tumor cells, the coordinated Ru(ii) centers acted as the PDT active sites, and the biocompatible polysaccharide β-cyclodextrins acted as the non-covalent linkers. Significantly, the resultant Ru/polysaccharide/protein exhibited not only specific targeting properties towards tumor cells but also high PDT ability under the irradiation of visible light. Furthermore, the assembly showed selective killing towards tumor cells along with negligible toxicity towards normal cells.
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ISSN:1359-7345
1364-548X
DOI:10.1039/c8cc09964b