Enabling a universal lateral flow readout for DNA strand displacement via disassembling chemical labels

Herein, we describe a novel strategy that enables lateral flow readout for DNA strand displacement disassembling chemical labels (DCL). Comparing it to a classic fluorogenic assay, we demonstrate that our DCL-based lateral flow assay is highly sensitive and specific, capable of discriminating single...

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Bibliographic Details
Published inChemical communications (Cambridge, England) Vol. 59; no. 57; pp. 8803 - 8805
Main Authors Peng, Wanting, Tan, Yun, Shen, Chenlan, Tang, Yanan, Li, Feng
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 13.07.2023
Subjects
Biosensing Techniques
Dismantling
DNA - genetics
Labels
Nucleotides
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Summary:Herein, we describe a novel strategy that enables lateral flow readout for DNA strand displacement disassembling chemical labels (DCL). Comparing it to a classic fluorogenic assay, we demonstrate that our DCL-based lateral flow assay is highly sensitive and specific, capable of discriminating single nucleotide variants in buccal swab samples.
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ISSN:1359-7345
1364-548X
DOI:10.1039/d3cc01743e