Mitochondria-targeted fluorophores for in vivo NIR-II imaging-guided PDT/PTT

A simple yet powerful D–A type-based NIR-II fluorophore (MTF) with mitochondria targeting was constructed. This mitochondrial targeting dye MTF exhibited not only a photothermal effect but also photodynamic performance, and was further fabricated with DSPE-mPEG to generate nanodots for in vivo exper...

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Published inChemical communications (Cambridge, England) Vol. 59; no. 52; pp. 8127 - 8130
Main Authors Ding, Qihang, Mei, Ling, Liu, Yu, Zhou, Shan, Chen, Lu, Liang, Yuying, Li, Mingle, Zhou, Hui, Yin, Chao, Kim, Jong Seung
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 27.06.2023
Royal Society of Chemistry
Subjects
Chemical compounds
Chemistry
Chemistry, Multidisciplinary
Mitochondria
Physical Sciences
Science & Technology
PHOTODYNAMIC THERAPY
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Summary:A simple yet powerful D–A type-based NIR-II fluorophore (MTF) with mitochondria targeting was constructed. This mitochondrial targeting dye MTF exhibited not only a photothermal effect but also photodynamic performance, and was further fabricated with DSPE-mPEG to generate nanodots for in vivo experiments, achieving strong NIR-II fluorescence tracing of tumors and impressive NIR-II image-guided photodynamic therapy (PDT) and photothermal therapy (PTT).
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ISSN:1359-7345
1364-548X
1364-548X
DOI:10.1039/D3CC02380J