Synthesis of chiral seven- membered beta- substituted lactams via Rh- catalyzed asymmetric hydrogenation

Rh/bisphosphine-thiourea ligand (ZhaoPhos)-catalyzed asymmetric hydrogenation of seven-membered -substituted ,-unsaturated lactams was successfully developed to prepare various chiral seven-membered -substituted lactams with good to excellent results (up to >99% conversion, 99% yield, and >99%...

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Published inOrganic & biomolecular chemistry Vol. 16; no. 45; pp. 8819 - 8823
Main Authors Huang, Yi, Li, Pan, Dong, Xiu-Qin, Zhang, Xumu
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 21.11.2018
Royal Society of Chemistry
Subjects
Chemical synthesis
Chemistry
Chemistry, Organic
Crystallography
Hydrogenation
NMR
Nuclear magnetic resonance
Physical Sciences
Science & Technology
Substitutes
Thiourea
REARRANGEMENT
HIGHLY ENANTIOSELECTIVE SYNTHESIS
AMINES
IMINES
IRON
LIGAND
VINYLAZIRIDINES
ACCESS
CONJUGATE ADDITION
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Summary:Rh/bisphosphine-thiourea ligand (ZhaoPhos)-catalyzed asymmetric hydrogenation of seven-membered -substituted ,-unsaturated lactams was successfully developed to prepare various chiral seven-membered -substituted lactams with good to excellent results (up to >99% conversion, 99% yield, and >99% ee).
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1477-0520
1477-0539
DOI:10.1039/c8ob02231c