Multi-responsive physical gels formed by a biosynthetic asymmetric triblock protein polymer and a polyanion

We report the design, production and characterization of a biosynthetic asymmetric triblock copolymer which consists of one collagen-like and one cationic block spaced by a hydrophilic random coiled block. The polymer associates into micelles when a polyanion is added due to the electrostatic intera...

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Published inSoft matter Vol. 9; no. 37; pp. 8923 - 8930
Main Authors Pham, Thao T. H., Wang, Junyou, Werten, M. W. T., Snijkers, Frank, de Wolf, F. A., Cohen Stuart, M. A., van der Gucht, J.
Format Journal Article
LanguageEnglish
Published 01.01.2013
Subjects
aggregation
aqueous-solution
Asymmetry
Block copolymers
Blocking
Cationic
chitosan
Coiling
complexes
controlled drug-delivery
hydrogels
Micelles
Proteins
Self assembly
temperature
terpolymers
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Summary:We report the design, production and characterization of a biosynthetic asymmetric triblock copolymer which consists of one collagen-like and one cationic block spaced by a hydrophilic random coiled block. The polymer associates into micelles when a polyanion is added due to the electrostatic interaction between the cationic block and the polyanion. The collagen-like block self-assembles into thermo-responsive triple helices upon cooling. When both end blocks are induced to self-assemble, a physical gel is formed viathermo-responsive association of the charge-driven micelles. The self-assembly of both end blocks and the effects of salt and temperature thereon were characterized by light scattering and rheology.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
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ISSN:1744-683X
1744-6848
DOI:10.1039/c3sm51751a