A case of neonatal Bartter's syndrome

We describe a child with a neonatal presentation of Bartter's syndrome. Unlike infants previously described with a similar clinical presentation, the urinary excretion rate of prostaglandin E2 in this child was similar to normal children and Tamm-Horsfall protein was distributed normally in the...

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Published inPediatric nephrology (Berlin, West) Vol. 10; no. 4; pp. 414 - 418
Main Authors Wong, W, Hulton, S A, Taylor, C M, Raafat, F, Lote, C J, Lindop, G
Format Journal Article
LanguageEnglish
Published Germany Springer Nature B.V 01.08.1996
Subjects
Angiotensin-Converting Enzyme Inhibitors - therapeutic use
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Bartter Syndrome - drug therapy
Bartter Syndrome - pathology
Captopril - therapeutic use
Dinoprostone - blood
Female
Humans
Indomethacin - therapeutic use
Infant
Kidney - pathology
Loop of Henle - pathology
Mucoproteins - metabolism
Pregnancy Proteins - metabolism
Uromodulin
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Summary:We describe a child with a neonatal presentation of Bartter's syndrome. Unlike infants previously described with a similar clinical presentation, the urinary excretion rate of prostaglandin E2 in this child was similar to normal children and Tamm-Horsfall protein was distributed normally in the thick ascending limb of the loop of Henle. The child failed to respond to indomethacin alone, but thrived after the addition of the angiotensin converting enzyme inhibitor, captopril.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
content type line 23
ObjectType-Report-1
ObjectType-Article-3
ISSN:0931-041X
1432-198X
DOI:10.1007/s004670050131