Acorus calamus Linn.: A novel neuroprotective approach for traumatic brain injury in Drosophila melanogaster

[Display omitted] Traumatic brain injury (TBI) causes substantial mortality and morbidity globally. Current treatments only alleviate symptoms and do not halt secondary injury progression. Evaluate the neuroprotective potential of Acorus calamus Linn. (AC) in a Drosophila melanogaster model of high-...

Full description

Saved in:
Bibliographic Details
Published inBrain research Vol. 1836; p. 148953
Main Authors Kalra, Sunishtha, Sachdeva, Himanshu, Bhushan Pant, Aditya, Singh, Govind
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.08.2024
Subjects
Acorus calamus Linn
Drosophila melanogaster
High-impact trauma
Secondary injury
Traumatic brain injury
AChE
NO
Traumatic brain injury
DTNB
TPC
High-impact trauma
Secondary injury
SOD
MDA
HIT
Acorus calamus Linn
CAT
TBI
HAEAC
GSH
Drosophila melanogaster
Online AccessGet full text

Cover

More Information
Summary:[Display omitted] Traumatic brain injury (TBI) causes substantial mortality and morbidity globally. Current treatments only alleviate symptoms and do not halt secondary injury progression. Evaluate the neuroprotective potential of Acorus calamus Linn. (AC) in a Drosophila melanogaster model of high-impact TBI. Fruit flies (Drosophila melanogaster) of the Oregon R + strain were administered hydroalcoholic extracts of Acorus calamus Linn. (HAEAC) at concentrations of 25 and 50 µg/mL, 24 h and continuously for 72 h, respectively, following TBI induction. Mortality rate, locomotor function, neurotransmitter levels, and oxidative stress markers were assessed at 24 and 72 h post-injury as outcomemeasures. AC significantly reduced post-TBI mortality and improved locomotor function in a dose-dependent manner. Additionally, AC increased acetylcholinesterase, gamma-aminobutyric acid, serotonin, and dopamine levels while reducing glutamate. It also boosted antioxidant activity (superoxide dismutase, glutathione, and catalase) and lowered markers of oxidative damage (malondialdehyde, nitrite). AC mitigated behavioral deficits, oxidative damage, and neurotransmitter imbalance in fruit flies after TBI. These findings indicate AC may be more effective than individual drugs for TBI therapy. Further research into its neuroprotective phytochemicals is warranted.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0006-8993
1872-6240
DOI:10.1016/j.brainres.2024.148953