Environmental stimulus-responsive mesoporous silica nanoparticles as anticancer drug delivery platforms

• Published in: Colloids and surfaces, B, Biointerfaces Vol. 234; p. 113758
• Main Authors: Zhao, Huanhuan, Li, Yan, Chen, Jiaxin, Zhang, Jinjia, Yang, Qiuqiong, Cui, Ji, Shi, Anhua, Wu, Junzi
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.02.2024
• Subjects: Anticancer drugs; Antineoplastic Agents - pharmacology; Antineoplastic Agents - therapeutic use; Drug Carriers; Drug delivery system; Drug Delivery Systems; Drug Liberation; Environmental stimulus responsiveness; Humans; Mesoporous silica nanoparticles; Nanoparticles - therapeutic use; Neoplasms - drug therapy; Porosity; Silicon Dioxide; Tumor Microenvironment; Mesoporous silica nanoparticles; Anticancer drugs; Environmental stimulus responsiveness; Drug delivery system
• ISSN: 0927-7765; 1873-4367
• DOI: 10.1016/j.colsurfb.2024.113758

Currently, cancer poses a significant health challenge in the medical community. Traditional chemotherapeutic agents are often accompanied by toxic side effects and limited therapeutic efficacy, restricting their application and advancement in cancer treatment. Therefore, there is an urgent need for developing intelligent drug release systems. Mesoporous silica nanoparticles (MSNs) have many advantages, such as a large specific surface area, substantial pore volume and size, adjustable mesoporous material pore size, excellent biocompatibility, and thermodynamic stability, making them ideal carriers for drug delivery and release. Additionally, they have been widely used to develop novel anticancer drug carriers. Recently, MSNs have been employed to design responsive systems that react to the tumor microenvironment and external stimuli for controlled release of anticancer drugs. This includes factors within the intratumor environment, such as pH, temperature, enzymes, and glutathione as well as external tumor stimuli, such as light, magnetic field, and ultrasound, among others. In this review, we discuss the research progress on environmental stimulus-responsive MSNs in anticancer drug delivery systems, including internal and external environment single stimulus-responsive release and combined stimulus-responsive release. We also summarize the current challenges associated with environmental stimulus-responsive MSNs and elucidate future directions, providing a reference for the functionalization modification and practical application of these MSNs. [Display omitted] ●Developing nanoparticle drug delivery systems with clinical applications.●Mesoporous silica nanoparticles have high drug loading.●Killing effect of environmental stimulus-responsive mesoporous silica nanoparticles on tumor cells.