Acute treatment with Mangifera indica L. leaf extract attenuates liver inflammation in rats fed a cafeteria diet

• Published in: Food & function Vol. 10; no. 8; pp. 4861 - 4867
• Main Authors: Toledo, Renata Celi Lopes, Brito, Larissa Froede, Caetano, Mônica Maria Magalhães, Nakajima, Vânia Mayumi, da Silva, Bárbara Pereira, Soares, Filippe Elias de Freitas, Martino, Hércia Stampini Duarte, de Queiroz, José Humberto
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 01.08.2019
• Subjects: Animals; Anti-inflammatory agents; Anti-Inflammatory Agents - administration & dosage; Body weight; Diet; Diet, High-Fat - adverse effects; Food intake; Gene expression; Hsp72 protein; Humans; Inflammation; Interleukin 10; Interleukin-10 - genetics; Interleukin-10 - immunology; Leaves; Liver; Liver - drug effects; Liver - immunology; Liver Diseases - drug therapy; Liver Diseases - etiology; Liver Diseases - genetics; Liver Diseases - immunology; Longitude; Male; Malondialdehyde; Malondialdehyde - immunology; Mangifera - chemistry; Mangifera indica; Mangoes; NF-κB protein; Peroxisome proliferator-activated receptors; Phytotherapy; Plant extracts; Plant Extracts - administration & dosage; Plant Leaves - chemistry; PPAR alpha - genetics; PPAR alpha - immunology; Proteins; Rats; Superoxide dismutase
• ISSN: 2042-6496; 2042-650X
• DOI: 10.1039/c9fo00651f

This study investigates the acute anti-inflammatory activity of Mangifera indica L. leaf extract and mangiferin in the liver of rats fed a cafeteria diet. This study was a randomized longitudinal experimental study. The animals were divided into three groups - Control: cafeteria diet (CD); Extract: CD + leaf extract (250 mg kg ); and Mangiferin: CD + mangiferin (40 mg kg ). Body weight and food intake were measured every week. On day eight, mRNA and protein expression of inflammatory markers were evaluated in the liver. Also, liver weight, SOD activity and malondialdehyde concentration were measured. Treatment for only eight days with mango leaf extract and mangiferin increased SOD activity. Mangiferin intake increased the mRNA expression of PPAR-α and HSP72. The leaf extract treatment enhanced PPAR-α mRNA expression. Mangiferin and leaf extract consumption caused a lower concentration of NFκB (p65) in nuclear extracts, and greater IL-10 mRNA and protein levels. This study highlights the potential of acute treatment with mango leaf extract and mangiferin to prevent liver inflammation caused by fat-rich diets. These results indicate a new use for a product that has low cost, is found in great amounts, and is not routinely used.