Grafted Vitamin-E UHMWPE may increase the durability of posterior stabilized and constrained condylar total knee replacements

The suitability of grafted vitamin-E highly crosslinked polyethylene (VE-HXPE) for use in posterior stabilized (PS) and constrained condylar knee (CCK) applications has not been explored. We hypothesized that VE-HXPE performs better than conventional and crosslinked polyethylene under clinically rel...

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Published inJournal of biomedical materials research. Part B, Applied biomaterials Vol. 105; no. 7; pp. 1789 - 1798
Main Authors Wernle, James D, Mimnaugh, Kimberly D, Rufner, Alicia S, Popoola, Oludele O, Argenson, Jean-Noel, Kelly, Michael
Format Journal Article
LanguageEnglish
Published United States Wiley Subscription Services, Inc 01.10.2017
Subjects
Arthroplasty, Replacement, Knee
Biomedical materials
Cholecystokinin
Cross-linked polyethylene
Delamination
Durability
Fatigue strength
Fracture toughness
Grafting
Humans
In vitro methods and tests
Knee
Knee Prosthesis
Load resistance
Materials fatigue
Materials research
Materials science
Materials Testing
Polyethylene
Polyethylenes - chemistry
Shear strength
Surgical implants
Torsional fatigue
Ultra high molecular weight polyethylene
Vitamin E - chemistry
Wear resistance
delamination
wear
UHMWPE
total knee replacements
Vitamin E
fracture
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Summary:The suitability of grafted vitamin-E highly crosslinked polyethylene (VE-HXPE) for use in posterior stabilized (PS) and constrained condylar knee (CCK) applications has not been explored. We hypothesized that VE-HXPE performs better than conventional and crosslinked polyethylene under clinically relevant conditions. PS tibial post fracture resistance under adverse shear loading conditions, CCK tibial post resistance to torsional fatigue, delamination resistance under high stress, and wear resistance were evaluated. Grafted VE-HXPE exhibits (1) 10% and 57% improved PS post fatigue strength compared to conventional PE (CPE) and remelted HXPE; (2) 45% improved CCK post fatigue strength compared to CPE; (3) Greater than 36× the delamination resistance of CPE; and (4) 96% and 73% wear reduction compared to CPE and HXPE. VE-HXPE performed well under clinically relevant in vitro conditions. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 1789-1798, 2017.
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ISSN:1552-4973
1552-4981
DOI:10.1002/jbm.b.33710