The impact of simultaneous intracranial recordings on scalp EEG: A finite element analysis

• Published in: Journal of neuroscience methods Vol. 405; p. 110101
• Main Authors: Wong, Simeon M., Sharma, Rohit, Abushama, Ahmed, Ochi, Ayako, Otsubo, Hiroshi, Ibrahim, George M.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.05.2024
• Subjects: Burr holes; Finite element analysis; Intracranial electroencephalography; Leadfield; Scalp electroencephalography; Simulation; Intracranial electroencephalography; Scalp electroencephalography; Leadfield; Finite element analysis; Simulation; Burr holes
• ISSN: 0165-0270; 1872-678X; 1872-678X
• DOI: 10.1016/j.jneumeth.2024.110101

In this study, we examined the utility of simultaneous scalp and stereotactic intracranial electroencephalography (SSIEEG) in epilepsy patients. Although SSIEEG offers valuable insights into epilepsy and cognitive function, its routine use is uncommon. Challenges include interpreting post-craniotomy scalp EEG due to surgically implanted electrodes. We describe our methodology for conducting SSIEEG recordings. To simulate the potential impact on EEG interpretation, we computed the leadfield of scalp electrodes with and without burrholes using Finite Element Analysis to compare the resulting sensitivity volume and waveforms of simulated intracranial signals between skulls with and without burrholes. The presence of burr holes in the skull layer of the leadfield models did not discernibly modify simulated waveforms or scalp EEG topology. Using realistic SEEG burr hole diameter, the difference in the average leadfield of scalp electrodes was 0.12% relative to the effect of switching two nearby electrodes, characterized by the cosine similarity difference. No patients experienced adverse events related to SSIEEG. Although there is increasing acceptance and interest in SSIEEG, few studies have characterized the technical feasibility. Here, we demonstrate through modelling that scalp recordings from SSIEEG are comparable to that through an intact skull. The placement and simultaneous acquisition of scalp EEG during invasive monitoring through stereotactically inserted EEG electrodes is routinely performed at the Hospital for Sick Children. Scalp EEG recordings may assist with clinical interpretation. Burr holes in the skull layer did not discernibly alter EEG waveforms or topology. •Finite element analysis is used to simulate SSIEEG.•Burrholes for stereotaxic EEG electrodes have minimal impact on the lead field.•In 31 consecutive cases, no adverse effects were reported.