Minocycline-induced vasculitis fulfilling the criteria of polyarteritis nodosa

Abstract A 47-year-old man who had been taking minocycline for palmoplantar pustulosis developed fever, myalgias, polyneuropathy, and testicular pain, with elevated C-reactive protein (CRP). Neither myeloperoxidase- nor proteinase-3-antineutrophil cytoplasmic antibody was positive. These manifestati...

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Bibliographic Details
Published inModern rheumatology Vol. 16; no. 4; pp. 256 - 259
Main Authors Katada, Yoshinori, Harada, Yoshinori, Azuma, Naoto, Matsumoto, Kengo, Terada, Haruko, Kudo, Eriko, Ishii, Masaru, Yamane, Hiroyuki, Yamamoto, Suguru, Ohshima, Shiro, Mima, Toru, Tanaka, Toshio, Saeki, Yukihiko
Format Journal Article
LanguageEnglish
Published United States Informa Healthcare 01.08.2006
Subjects
Anti-Bacterial Agents - adverse effects
Arthralgia - chemically induced
C-Reactive Protein - metabolism
Humans
Male
Middle Aged
Minocycline - adverse effects
Paresthesia - chemically induced
Polyarteritis Nodosa - chemically induced
Psoriasis - drug therapy
Testis
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Summary:Abstract A 47-year-old man who had been taking minocycline for palmoplantar pustulosis developed fever, myalgias, polyneuropathy, and testicular pain, with elevated C-reactive protein (CRP). Neither myeloperoxidase- nor proteinase-3-antineutrophil cytoplasmic antibody was positive. These manifestations met the American College of Rheumatology 1990 criteria for the classification of polyarteritis nodosa. Stopping minocycline led to amelioration of symptoms and normalization of CRP level. To our knowledge, this is the second case of minocycline-induced vasculitis satisfying the criteria. Differential diagnosis for drug-induced disease is invaluable even for patients with classical polyarteritis nodosa.
ISSN:1439-7595
1439-7609
DOI:10.3109/s10165-006-0492-4