Collagenofibrotic glomerulopathy in a kidney transplant recipient: A first report

• Published in: American journal of transplantation Vol. 21; no. 5; pp. 1948 - 1952
• Main Authors: Jdiaa, Sara S., Moeckel, Gilbert W., Kfoury, Hala M., Medawar, Walid A., Abu‐Alfa, Ali K.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Limited 01.05.2021
• Subjects: Case reports; clinical research/practice; Collagen; Collagen Type III; Electron microscopy; Fibrils; genetics; Hematuria; Humans; Kidney diseases; Kidney Diseases - etiology; Kidney Glomerulus; Kidney transplantation; Kidney Transplantation - adverse effects; kidney transplantation/nephrology; Kidney transplants; Medical diagnosis; Periodicity; Proteinuria; Rare diseases; recurrent disease; Renal function; genetics; recurrent disease; clinical research/practice; kidney transplantation/nephrology
• ISSN: 1600-6135; 1600-6143
• DOI: 10.1111/ajt.16399

Collagenofibrotic glomerulopathy (CG) is a rare disease characterized by the deposition of collagen type 3 fibrils in the glomeruli. Patients may have proteinuria, hematuria, and/or renal dysfunction. CG is considered a progressive disease with variable rates of progression. The definitive diagnosis is made by electron microscopy with the presence of characteristic subendothelial and mesangial curved, comma‐like, banded collagen type 3 fibers of 40–65 nm periodicity. We are reporting the first case of CG in a kidney transplant recipient with kidney disease of unknown cause. The authors describe a case of biopsy‐proven collagenofibrotic glomerulopathy in a kidney transplant recipient, emphasizing the importance of considering uncommon etiologies of allograft dysfunction in recipients with unknown primary kidney disease.