Neurotropic melanoma invading the median nerve

We report a case of acral lentiginous melanoma of the right thumbnail bed which demonstrated characteristic intraneural invasion and extension along the median nerve. Four years after amputation of the involved thumb, a melanotic tumor recurred on the right thenar. Radiation therapy was given. The t...

Full description

Saved in:
Bibliographic Details
Published inJournal of dermatology Vol. 25; no. 6; p. 379
Main Authors Iyadomi, M, Ohtsubo, H, Gotoh, Y, Kohda, H, Narisawa, Y
Format Journal Article
LanguageEnglish
Published England 01.06.1998
Subjects
Amputation
Arm - surgery
Fatal Outcome
Female
Humans
Median Nerve - pathology
Median Nerve - surgery
Melanoma - pathology
Melanoma - secondary
Melanoma - surgery
Middle Aged
Nail Diseases - pathology
Nail Diseases - surgery
Neoplasm Invasiveness
Neoplasm Recurrence, Local - pathology
Peripheral Nervous System Neoplasms - pathology
Peripheral Nervous System Neoplasms - surgery
S100 Proteins - analysis
Thumb - pathology
Thumb - surgery
Online AccessGet more information

Cover

More Information
Summary:We report a case of acral lentiginous melanoma of the right thumbnail bed which demonstrated characteristic intraneural invasion and extension along the median nerve. Four years after amputation of the involved thumb, a melanotic tumor recurred on the right thenar. Radiation therapy was given. The tumor invaded the median nerve, however, causing progressive pain and paralysis of the right hand. Despite right arm amputation, the tumor extensively metastasized, and the patient died three years later. Histopathologically, the tumors were characterized by extensive proliferation of spindle-shaped cells forming neuroid fascicles especially prominent in the metastatic region. Tumor cells were positive immunohistochemically with S-100 protein antisera.
ISSN:0385-2407
DOI:10.1111/j.1346-8138.1998.tb02418.x