Effects of cerebrolysin on moderate cognitive impairments in cerebral vascular insufficiency (a clinical-electrophysiological study)

• Published in: Neuroscience and behavioral physiology Vol. 38; no. 6; pp. 639 - 645
• Main Authors: Damulin, I. V., Koberskaya, N. N., Mkhitaryan, É. A.
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.07.2008; Springer Nature B.V
• Subjects: Adult; Aged; Aged, 80 and over; Amino Acids - therapeutic use; Attention - drug effects; Behavioral Sciences; Biomedical and Life Sciences; Biomedicine; Brain - blood supply; Brain - drug effects; Brain - physiopathology; Cerebrovascular Disorders - complications; Cerebrovascular Disorders - drug therapy; Cognition Disorders - etiology; Cognition Disorders - prevention & control; Concept Formation - drug effects; Event-Related Potentials, P300 - drug effects; Female; Humans; Male; Middle Aged; Neurobiology; Neuropsychological Tests; Neurosciences; Neurotensin - physiology; Nootropic Agents - therapeutic use; Problem Solving - drug effects; Severity of Illness Index; Statistics, Nonparametric; cerebral vascular insufficiency; impairment of cognitive functions; 300 cognitive evoked potentials; cerebrolysin
• ISSN: 0097-0549; 1573-899X
• DOI: 10.1007/s11055-008-9014-5

The efficacy of treatment with cerebrolysin was studied in 40 patients with cerebral vascular insufficiency. Cerebrolysin (20 daily i.v. infusions of 10 ml in 200 ml of physiological saline) was found to be an effective means of treating this group of patients. Courses of cerebrolysin treatment decreased the severity of memory and attention impairments, improving the overall cognitive status of the patients. Clinical observations and neuropsychological testing were supported by electrophysiological results, in terms of the P300 cognitive evoked potential. The effects of treatment at the doses used here were delayed and were seen three months after completion of treatment.