The Potential of microRNAs for Stem Cell-based Therapy for Degenerative Skeletal Diseases

Purpose of Review Degenerative skeletal disorders including osteoarthritis (OA) and osteoporosis (OP) are the result of attenuation of tissue regeneration and lead to painful conditions with limited treatment options. Preventative measures to limit the onset of OA and OP remain a significant unmet c...

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Published inCurrent molecular biology reports Vol. 3; no. 4; pp. 263 - 275
Main Authors Budd, Emma, Waddell, Shona, de Andrés, María C., Oreffo, Richard O. C.
Format Journal Article
LanguageEnglish
Published Cham Springer International Publishing 2017
Springer Nature B.V
Subjects
Biomedical and Life Sciences
Biomedicine
Cartilage (articular)
Cartilage diseases
Human Genetics
MicroRNAs
miRNA
Molecular Biology of Skeletal Tissue Engineering (D Hutmacher
Molecular Biology of Skeletal Tissue Engineering (D Hutmacher, Section Editor)
Molecular Medicine
Osteoarthritis
Osteoporosis
Regenerative medicine
Section Editor
Stem cells
Topical Collection on Molecular Biology of Skeletal Tissue Engineering
Cartilage
Osteoporosis
miRNA
Bone
Skeletal stem cell
Osteoarthritis
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Summary:Purpose of Review Degenerative skeletal disorders including osteoarthritis (OA) and osteoporosis (OP) are the result of attenuation of tissue regeneration and lead to painful conditions with limited treatment options. Preventative measures to limit the onset of OA and OP remain a significant unmet clinical need. MicroRNAs (miRNAs) are known to be involved in the differentiation of stem cells, and in combination with stem cell therapy could induce skeletal regeneration and potentially prevent OA and OP onset. Recent Findings The combination of stem cells and miRNA has been successful at regenerating the bone and cartilage in vivo. MiRNAs, including miR-146b known to be involved in chondrogenic differentiation, could provide innovative targets for stem cell-based therapy, for the repair of articular cartilage defects forestalling the onset of OA or in the generation of a stem cell-based therapy for OP. Summary This review discusses the combination of skeletal stem cells (SSCs) and candidate miRNAs for application in a cell-based therapy approach for skeletal regenerative medicine.
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ISSN:2198-6428
2198-6428
DOI:10.1007/s40610-017-0076-4