Infections with Salmonella typhimurium and Nippostrongylus brasiliensis in mice selectively reared for high or low immune responsiveness to Nematospiroides dubius

Mice which had been selectively reared over six generations for high (H) and low (L) immune responsiveness to N. dubius (Sitepu and Dobson, 1982) were infected with Salmonella typhimurium and N. brasiliensis to examine the specificity of the selection process for heterologous infections. H mice were...

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Published inAustralian journal of experimental biology and medical science Vol. 62 ( Pt 6); p. 755
Main Authors Sitepu, P, Dobson, C, Brindley, P J
Format Journal Article
LanguageEnglish
Published Australia 01.12.1984
Subjects
Animals
Female
Male
Mice
Nematode Infections - genetics
Nematode Infections - immunology
Nippostrongylus
Salmonella Infections, Animal - genetics
Salmonella Infections, Animal - immunology
Salmonella typhimurium
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Summary:Mice which had been selectively reared over six generations for high (H) and low (L) immune responsiveness to N. dubius (Sitepu and Dobson, 1982) were infected with Salmonella typhimurium and N. brasiliensis to examine the specificity of the selection process for heterologous infections. H mice were marginally more susceptible than L mice to S. typhimurium, whereas H mice were more resistant to infection with N. brasiliensis than L mice. Both H and L mice were protected against N. dubius following immunization with N. brasiliensis larvae.
ISSN:0004-945X
DOI:10.1038/icb.1984.71