Application of derivative spectrophotometry for determination of coenzyme Q10 in pharmaceuticals and plasma

The use of derivative spectrophotometry is proposed in this work for determination of coenzyme Q10 in formulations and in human plasma. The spectrophotometric procedure is simpler and less expensive than chromatographic techniques commonly used for the analysis of coenzyme. The active compound can b...

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Bibliographic Details
Published inJournal of pharmaceutical and biomedical analysis Vol. 17; no. 8; pp. 1345 - 1350
Main Authors KARPINSKA, J, MIKOŁUC, B, PIOTROWSKA-JASTRZEBSKA, J
Format Journal Article
LanguageEnglish
Published Amsterdam Elsevier Science 01.09.1998
Subjects
Analysis
Antioxidants - analysis
Biological and medical sciences
Capsules
Chromatography, High Pressure Liquid
Coenzymes
General pharmacology
Humans
Medical sciences
Pharmacology. Drug treatments
Spectrophotometry - instrumentation
Spectrophotometry - methods
Ubiquinone - analogs & derivatives
Ubiquinone - analysis
Ubiquinone - blood
Human
Biological fluid
Ubiquinone
Derivative spectrometry
Dosage form
Hard capsule
Ultraviolet spectrometry
Quantitative analysis
Blood plasma
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Summary:The use of derivative spectrophotometry is proposed in this work for determination of coenzyme Q10 in formulations and in human plasma. The spectrophotometric procedure is simpler and less expensive than chromatographic techniques commonly used for the analysis of coenzyme. The active compound can be determined in the range 0.25-10 ppm for standard solutions and pharmaceuticals and 0.05-1.5 ppm in plasma. The proposed method was applied for coenzyme determination in real samples. The results agree well with declared value and with these obtained by HPLC.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0731-7085
1873-264X
DOI:10.1016/s0731-7085(98)00003-x