Role of angiotensin II in extracellular matrix and transforming growth factor-β1 expression in hypertensive rats

• Published in: European journal of pharmacology. Molecular pharmacology section Vol. 269; no. 1; pp. 115 - 119
• Main Authors: Ohta, Kensuke, Kim, Shokei, Hamaguchi, Akinori, Yukimura, Tokihito, Miura, Katsuyuki, Takaori, Kazuo, Iwao, Hiroshi
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.09.1994; Elsevier
• Subjects: Arterial hypertension. Arterial hypotension; Biological and medical sciences; Blood and lymphatic vessels; Cardiology. Vascular system; Cardiovascular system; Experimental diseases; Extracellular matrix; Medical sciences; mRNA; Renin-angiotensin system; SHR; Spontaneously hypertensive rat; Transforming growth factor β1; Cardiovascular system; Extracellular matrix; mRNA; SHR; Renin-angiotensin system; Transforming growth factor β 1; Hypertension; Rat; Transforming growth factor β; Pathogenesis; Spontaneous; Peptide hormone; Rodentia; Cardiovascular disease; Gene expression; Fibronectin; Vertebrata; Renin angiotensin system; Mammalia; Laminin; Animal; Collagen; Angiotensin II
• ISSN: 0922-4106
• DOI: 10.1016/0922-4106(94)90033-7

The in vivo effects of alacepril (1-[(S)-3-acetylthio-2-methylpropanoyl]- L-prolyl- L-phenylalanine), an angiotensin converting enzyme inhibitor, and SC-52458 (5-[(3,5-dibutyl-1H-1,2,4-triazol-1-yl)methyl]-2-[2-(1H-tetrazol-5-ylphenyl)]pyridine), an angiotensin AT 1 receptor antagonist, were examined on the cardiac and aortic gene expressions of extracellular matrices and TGF-β1 in young spontaneously hypertensive rats (SHR). In SHR, types I and III collagen mRNAs were increased in the left ventricle, and in contrast, fibronectin, collagen IV, and transforming growth factor-β1 (TGF-β1) mRNAs were increased in aorta, compared with those in Wistar-Kyoto rats. All the enhanced mRNAs in both organs in SHR were significantly inhibited by the short-term treatment with the above two drugs. Thus, angiotensin AT 1 receptor may play an important role in the regulation of extracellular matrices and TGF-β1 expressions in SHR.