Supramolecular imaging of spermine in cancer cells

As an important biomarker, the overexpressed spermine has been widely investigated for cancer diagnosis and treatment. However, bioimaging of spermine in living cells is still a formidable challenge. Herein, we design a supramolecular imaging ensemble for spermine by the host-guest complexation of a...

Full description

Saved in:
Bibliographic Details
Published inNanoscale Vol. 13; no. 36; pp. 15362 - 15368
Main Authors Tian, Han-Wen, Chang, Yu-Xuan, Hu, Xin-Yue, Shah, Muhammad Raza, Li, Hua-Bin, Guo, Dong-Sheng
Format Journal Article
LanguageEnglish
Published Cambridge Royal Society of Chemistry 23.09.2021
Subjects
Assembling
Assembly
Biocompatibility
Biomarkers
Cancer
Complexation
Fluorescence
Medical imaging
Online AccessGet full text

Cover

Abstract As an important biomarker, the overexpressed spermine has been widely investigated for cancer diagnosis and treatment. However, bioimaging of spermine in living cells is still a formidable challenge. Herein, we design a supramolecular imaging ensemble for spermine by the host-guest complexation of amphiphilic sulfonatocalix[5]arene (SC5A12C) assembly with lucigenin (LCG). Strong binding ability and complexation-induced fluorescence quenching properties enable SC5A12C to quench the fluorescence of LCG dramatically and to recover it completely due to the competition of overexpressed spermine in cancer cells. SC5A12C also exhibits excellent biocompatibility and promotes cellular uptake due to its ability to form ultra-stable assembly. Co-assembling folate further promotes the cellular uptake of folate receptor overexpressed cancer cells, contributing to enhanced bioimaging. A supramolecular imaging ensemble for spermine is developed by the complexation of amphiphilic sulfonatocalix[5]arene (SC5A12C) assembly with lucigenin.
AbstractList As an important biomarker, the overexpressed spermine has been widely investigated for cancer diagnosis and treatment. However, bioimaging of spermine in living cells is still a formidable challenge. Herein, we design a supramolecular imaging ensemble for spermine by the host-guest complexation of amphiphilic sulfonatocalix[5]arene (SC5A12C) assembly with lucigenin (LCG). Strong binding ability and complexation-induced fluorescence quenching properties enable SC5A12C to quench the fluorescence of LCG dramatically and to recover it completely due to the competition of overexpressed spermine in cancer cells. SC5A12C also exhibits excellent biocompatibility and promotes cellular uptake due to its ability to form ultra-stable assembly. Co-assembling folate further promotes the cellular uptake of folate receptor overexpressed cancer cells, contributing to enhanced bioimaging.As an important biomarker, the overexpressed spermine has been widely investigated for cancer diagnosis and treatment. However, bioimaging of spermine in living cells is still a formidable challenge. Herein, we design a supramolecular imaging ensemble for spermine by the host-guest complexation of amphiphilic sulfonatocalix[5]arene (SC5A12C) assembly with lucigenin (LCG). Strong binding ability and complexation-induced fluorescence quenching properties enable SC5A12C to quench the fluorescence of LCG dramatically and to recover it completely due to the competition of overexpressed spermine in cancer cells. SC5A12C also exhibits excellent biocompatibility and promotes cellular uptake due to its ability to form ultra-stable assembly. Co-assembling folate further promotes the cellular uptake of folate receptor overexpressed cancer cells, contributing to enhanced bioimaging.
As an important biomarker, the overexpressed spermine has been widely investigated for cancer diagnosis and treatment. However, bioimaging of spermine in living cells is still a formidable challenge. Herein, we design a supramolecular imaging ensemble for spermine by the host–guest complexation of amphiphilic sulfonatocalix[5]arene (SC5A12C) assembly with lucigenin (LCG). Strong binding ability and complexation-induced fluorescence quenching properties enable SC5A12C to quench the fluorescence of LCG dramatically and to recover it completely due to the competition of overexpressed spermine in cancer cells. SC5A12C also exhibits excellent biocompatibility and promotes cellular uptake due to its ability to form ultra-stable assembly. Co-assembling folate further promotes the cellular uptake of folate receptor overexpressed cancer cells, contributing to enhanced bioimaging.
As an important biomarker, the overexpressed spermine has been widely investigated for cancer diagnosis and treatment. However, bioimaging of spermine in living cells is still a formidable challenge. Herein, we design a supramolecular imaging ensemble for spermine by the host-guest complexation of amphiphilic sulfonatocalix[5]arene (SC5A12C) assembly with lucigenin (LCG). Strong binding ability and complexation-induced fluorescence quenching properties enable SC5A12C to quench the fluorescence of LCG dramatically and to recover it completely due to the competition of overexpressed spermine in cancer cells. SC5A12C also exhibits excellent biocompatibility and promotes cellular uptake due to its ability to form ultra-stable assembly. Co-assembling folate further promotes the cellular uptake of folate receptor overexpressed cancer cells, contributing to enhanced bioimaging. A supramolecular imaging ensemble for spermine is developed by the complexation of amphiphilic sulfonatocalix[5]arene (SC5A12C) assembly with lucigenin.
Author Hu, Xin-Yue
Guo, Dong-Sheng
Li, Hua-Bin
Tian, Han-Wen
Shah, Muhammad Raza
Chang, Yu-Xuan
AuthorAffiliation Key Laboratory of Functional Polymer Materials (Ministry of Education)
H.E.J. Research Institute of Chemistry
Nankai University
College of Chemistry
Tianjin Key Laboratory of Biosensing and Molecular Recognition
State Key Laboratory of Elemento-Organic Chemistry
University of Karachi
International Center for Chemical and Biological Sciences (ICCBS)
AuthorAffiliation_xml – name: International Center for Chemical and Biological Sciences (ICCBS)
– name: Key Laboratory of Functional Polymer Materials (Ministry of Education)
– name: State Key Laboratory of Elemento-Organic Chemistry
– name: Tianjin Key Laboratory of Biosensing and Molecular Recognition
– name: H.E.J. Research Institute of Chemistry
– name: University of Karachi
– name: College of Chemistry
– name: Nankai University
Author_xml – sequence: 1
  givenname: Han-Wen
  surname: Tian
  fullname: Tian, Han-Wen
– sequence: 2
  givenname: Yu-Xuan
  surname: Chang
  fullname: Chang, Yu-Xuan
– sequence: 3
  givenname: Xin-Yue
  surname: Hu
  fullname: Hu, Xin-Yue
– sequence: 4
  givenname: Muhammad Raza
  surname: Shah
  fullname: Shah, Muhammad Raza
– sequence: 5
  givenname: Hua-Bin
  surname: Li
  fullname: Li, Hua-Bin
– sequence: 6
  givenname: Dong-Sheng
  surname: Guo
  fullname: Guo, Dong-Sheng
BookMark eNptkc1LxDAQxYOs4O7qxbtQ8CJCNckkTXuUdf2ARcGPc4lpsmRpk5q0B_97W1dWWDzNHH7v8ebNDE2cdxqhU4KvCIbiuiIuYAY01wdoSjHDKYCgk92esSM0i3GDcVZABlNEX_s2yMbXWvW1DIlt5Nq6deJNElsdGut0Yl2ipFM6JErXdTxGh0bWUZ_8zjl6v1u-LR7S1fP94-JmlSogrEuNxJJxyIFiKtQHMMq5Ak4VVwYLELowgomBqYShqigKBoJJUWme57LCGczRxda3Df6z17ErGxvHBNJp38eSckEwB87wgJ7voRvfBzekGylOOQE2Gl5uKRV8jEGbsg3DveGrJLgc6ytvydPLT33LAcZ7sLKd7Kx3XZC2_l9ytpWEqHbWfx-Bb0zVe1s
CitedBy_id crossref_primary_10_1515_pac_2024_0320
crossref_primary_10_1016_j_colsurfa_2022_129146
crossref_primary_10_3390_molecules27092967
crossref_primary_10_1021_acs_accounts_3c00585
crossref_primary_10_1021_acs_analchem_2c01103
crossref_primary_10_1002_cptc_202300018
crossref_primary_10_1016_j_cjph_2023_05_021
crossref_primary_10_1021_acssensors_3c00886
crossref_primary_10_1002_adhm_202401778
crossref_primary_10_1038_s41467_022_31986_x
crossref_primary_10_3390_bios12080633
crossref_primary_10_1039_D4TB00668B
crossref_primary_10_1016_j_snb_2023_133757
crossref_primary_10_1080_10610278_2022_2087523
crossref_primary_10_1039_D2TB01269C
crossref_primary_10_1021_acsapm_3c02295
crossref_primary_10_1016_j_snb_2021_131302
crossref_primary_10_1021_acs_jcim_2c00483
crossref_primary_10_1021_acsami_2c12822
Cites_doi 10.7150/thno.33459
10.1021/acsami.7b01157
10.1016/j.jbiotec.2009.09.007
10.1023/A:1008155823862
10.31635/ccschem.019.20180036
10.1016/j.biocel.2009.07.009
10.1007/s10847-004-5098-x
10.1080/10610278.2017.1413243
10.1016/j.jconrel.2020.05.008
10.1016/j.talanta.2018.05.086
10.1021/la204004h
10.1021/ac800834n
10.1016/j.snb.2017.10.172
10.1016/j.snb.2018.01.197
10.1002/chem.201102060
10.1038/nrc1454
10.1039/C5RA07761C
10.1039/C4CC08721F
10.1039/b909682e
10.1080/10610278.2015.1125900
10.1080/10610278.2020.1857762
10.1021/acs.chemrev.8b00605
10.1002/bmc.3059
10.1016/j.jchromb.2014.11.037
10.1002/anie.201813397
10.1016/S0169-409X(99)00062-9
10.1007/s00726-019-02799-y
10.1039/C9QM00489K
10.1038/s41467-019-11553-7
10.1038/srep02372
10.6060/mhc170518r
10.1021/cr200213s
10.1016/S0043-1354(98)00170-5
10.1039/C6CC05761F
10.1039/C8CC09432B
10.1007/s11051-013-1649-7
10.1038/s41568-018-0050-3
10.1074/jbc.M602756200
10.1002/anie.201407808
10.1016/0009-3084(84)90032-X
10.1007/s11095-019-2608-5
10.1016/j.biomaterials.2018.02.051
10.1038/s41551-018-0234-x
10.1016/j.snb.2018.05.050
10.1021/acsami.9b09059
10.1016/j.clnu.2004.11.001
10.1021/jacs.7b13298
10.1016/0022-1759(93)90382-H
10.1021/acsami.7b19784
10.1002/iub.1237
10.1002/ijch.201900032
10.31635/ccschem.020.202000124
10.1021/bi300836r
10.1016/j.molliq.2019.01.132
10.1021/acsami.6b08295
10.1021/acs.langmuir.8b00290
10.1039/C5CC07861J
10.1039/c2cc32228e
ContentType Journal Article
Copyright Copyright Royal Society of Chemistry 2021
Copyright_xml – notice: Copyright Royal Society of Chemistry 2021
DBID AAYXX
CITATION
7SR
7U5
8BQ
8FD
F28
FR3
JG9
L7M
7X8
DOI 10.1039/d1nr04328e
DatabaseName CrossRef
Engineered Materials Abstracts
Solid State and Superconductivity Abstracts
METADEX
Technology Research Database
ANTE: Abstracts in New Technology & Engineering
Engineering Research Database
Materials Research Database
Advanced Technologies Database with Aerospace
MEDLINE - Academic
DatabaseTitle CrossRef
Materials Research Database
Engineered Materials Abstracts
Technology Research Database
Solid State and Superconductivity Abstracts
Engineering Research Database
Advanced Technologies Database with Aerospace
ANTE: Abstracts in New Technology & Engineering
METADEX
MEDLINE - Academic
DatabaseTitleList MEDLINE - Academic
Materials Research Database

CrossRef
DeliveryMethod fulltext_linktorsrc
Discipline Engineering
EISSN 2040-3372
EndPage 15368
ExternalDocumentID 10_1039_D1NR04328E
d1nr04328e
GroupedDBID -
0-7
0R
29M
4.4
53G
705
7~J
AAEMU
AAGNR
AAIWI
AAJAE
AANOJ
AAPBV
ABASK
ABDVN
ABGFH
ABRYZ
ACGFS
ACIWK
ACLDK
ADMRA
ADSRN
AENEX
AFVBQ
AGRSR
AGSTE
AGSWI
ALMA_UNASSIGNED_HOLDINGS
ANUXI
ASKNT
AUDPV
AZFZN
BLAPV
BSQNT
C6K
CKLOX
DU5
EBS
ECGLT
EE0
EF-
F5P
HZ
H~N
J3I
JG
O-G
O9-
OK1
P2P
RCNCU
RIG
RNS
RPMJG
RRC
RSCEA
---
0R~
AARTK
AAWGC
AAXHV
AAYXX
ABEMK
ABJNI
ABPDG
ABXOH
AEFDR
AENGV
AESAV
AETIL
AFLYV
AFOGI
AFRDS
AFRZK
AGEGJ
AHGCF
AKBGW
AKMSF
ALUYA
APEMP
CITATION
GGIMP
H13
HZ~
RAOCF
RVUXY
7SR
7U5
8BQ
8FD
F28
FR3
JG9
L7M
7X8
ID FETCH-LOGICAL-c314t-fa0a453832027cb34255c352c5cf0737e9f7470a4d7f2c9994374a7de588ad063
ISSN 2040-3364
2040-3372
IngestDate Fri Jul 11 07:28:51 EDT 2025
Sun Jun 29 16:52:37 EDT 2025
Thu Apr 24 23:04:37 EDT 2025
Tue Jul 01 01:14:13 EDT 2025
Mon May 02 04:31:10 EDT 2022
IsPeerReviewed true
IsScholarly true
Issue 36
Language English
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-c314t-fa0a453832027cb34255c352c5cf0737e9f7470a4d7f2c9994374a7de588ad063
Notes 10.1039/d1nr04328e
Electronic supplementary information (ESI) available. See DOI
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ORCID 0000-0002-0765-5427
0000-0003-4978-3627
PQID 2575251346
PQPubID 2047485
PageCount 7
ParticipantIDs crossref_citationtrail_10_1039_D1NR04328E
rsc_primary_d1nr04328e
crossref_primary_10_1039_D1NR04328E
proquest_miscellaneous_2571053540
proquest_journals_2575251346
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 20210923
PublicationDateYYYYMMDD 2021-09-23
PublicationDate_xml – month: 9
  year: 2021
  text: 20210923
  day: 23
PublicationDecade 2020
PublicationPlace Cambridge
PublicationPlace_xml – name: Cambridge
PublicationTitle Nanoscale
PublicationYear 2021
Publisher Royal Society of Chemistry
Publisher_xml – name: Royal Society of Chemistry
References Tripathi (D1NR04328E/cit13) 2018; 270
Zhang (D1NR04328E/cit48) 1999; 33
Kim (D1NR04328E/cit9) 2016; 52
Kumar (D1NR04328E/cit29) 2019; 119
Provenzano (D1NR04328E/cit6) 2019; 51
Gaspar (D1NR04328E/cit52) 2012; 51
Mutihac (D1NR04328E/cit35) 2005; 51
Casero Jr. (D1NR04328E/cit5) 2018; 18
Wallyn (D1NR04328E/cit26) 2019; 36
Min (D1NR04328E/cit54) 2014; 28
Sudimack (D1NR04328E/cit56) 2000; 41
Basilio (D1NR04328E/cit50) 2012; 28
Buschmann (D1NR04328E/cit34) 2001; 39
Zheng (D1NR04328E/cit59) 2010; 145
Yu (D1NR04328E/cit27) 2019; 9
Kim (D1NR04328E/cit15) 2011; 17
Garin-Chesa (D1NR04328E/cit55) 1993; 142
Graham (D1NR04328E/cit58) 2013; 15
Kramp (D1NR04328E/cit47) 1984; 35
Hao (D1NR04328E/cit20) 2018; 10
Khlebtsov (D1NR04328E/cit51) 2008; 80
Cheng (D1NR04328E/cit32) 2015; 5
Tu (D1NR04328E/cit12) 2016; 52
Chen (D1NR04328E/cit22) 2018; 178
Zheng (D1NR04328E/cit42) 2020
Dsouza (D1NR04328E/cit30) 2011; 111
Ryzhkina (D1NR04328E/cit46) 2017; 10
Kostereli (D1NR04328E/cit10) 2012; 48
Ding (D1NR04328E/cit24) 2019; 11
Geng (D1NR04328E/cit43) 2019; 58
Su (D1NR04328E/cit7) 2015; 978–979
Chen (D1NR04328E/cit25) 2019; 10
Hu (D1NR04328E/cit38) 2020; 324
Zheng (D1NR04328E/cit36) 2019; 59
Wang (D1NR04328E/cit45) 2015; 51
D'Urso (D1NR04328E/cit33) 2016; 28
Rodriguez-Caso (D1NR04328E/cit53) 2006; 281
Cheng (D1NR04328E/cit23) 2019; 55
Chen (D1NR04328E/cit21) 2017; 9
Pan (D1NR04328E/cit37) 2020; 2
Norouzy (D1NR04328E/cit40) 2015; 54
Tian (D1NR04328E/cit41) 2017; 30
Tawfik (D1NR04328E/cit16) 2018; 257
Chen (D1NR04328E/cit19) 2016; 8
Liu (D1NR04328E/cit11) 2013; 3
Fan (D1NR04328E/cit49) 2018; 34
ter Huurne (D1NR04328E/cit39) 2019; 1
Garthwaite (D1NR04328E/cit8) 1993; 162
Pegg (D1NR04328E/cit1) 2014; 66
Bhamore (D1NR04328E/cit14) 2019; 280
Lu (D1NR04328E/cit44) 2018; 2
Moinard (D1NR04328E/cit4) 2005; 24
Tanima (D1NR04328E/cit31) 2009; 7
Igarashi (D1NR04328E/cit3) 2010; 42
Yuan (D1NR04328E/cit18) 2018; 188
Tian (D1NR04328E/cit57) 2020; 4
Gerner (D1NR04328E/cit2) 2004; 4
Jiang (D1NR04328E/cit17) 2018; 261
Beatty (D1NR04328E/cit28) 2018; 140
References_xml – volume: 9
  start-page: 4624
  year: 2019
  ident: D1NR04328E/cit27
  publication-title: Theranostics
  doi: 10.7150/thno.33459
– volume: 9
  start-page: 8602
  year: 2017
  ident: D1NR04328E/cit21
  publication-title: ACS Appl. Mater. Interfaces
  doi: 10.1021/acsami.7b01157
– volume: 145
  start-page: 47
  year: 2010
  ident: D1NR04328E/cit59
  publication-title: J. Biotechnol.
  doi: 10.1016/j.jbiotec.2009.09.007
– volume: 39
  start-page: 1
  year: 2001
  ident: D1NR04328E/cit34
  publication-title: J. Inclusion Phenom. Macrocyclic Chem.
  doi: 10.1023/A:1008155823862
– volume: 1
  start-page: 64
  year: 2019
  ident: D1NR04328E/cit39
  publication-title: CCS Chem.
  doi: 10.31635/ccschem.019.20180036
– volume: 42
  start-page: 39
  year: 2010
  ident: D1NR04328E/cit3
  publication-title: Int. J. Biochem. Cell Biol.
  doi: 10.1016/j.biocel.2009.07.009
– volume: 51
  start-page: 1
  year: 2005
  ident: D1NR04328E/cit35
  publication-title: J. Inclusion Phenom. Macrocyclic Chem.
  doi: 10.1007/s10847-004-5098-x
– volume: 30
  start-page: 562
  year: 2017
  ident: D1NR04328E/cit41
  publication-title: Supramol. Chem.
  doi: 10.1080/10610278.2017.1413243
– volume: 324
  start-page: 124
  year: 2020
  ident: D1NR04328E/cit38
  publication-title: J. Controlled Release
  doi: 10.1016/j.jconrel.2020.05.008
– volume: 188
  start-page: 218
  year: 2018
  ident: D1NR04328E/cit18
  publication-title: Talanta
  doi: 10.1016/j.talanta.2018.05.086
– volume: 28
  start-page: 2404
  year: 2012
  ident: D1NR04328E/cit50
  publication-title: Langmuir
  doi: 10.1021/la204004h
– volume: 80
  start-page: 6620
  year: 2008
  ident: D1NR04328E/cit51
  publication-title: Anal. Chem.
  doi: 10.1021/ac800834n
– volume: 257
  start-page: 734
  year: 2018
  ident: D1NR04328E/cit16
  publication-title: Sens. Actuators, B
  doi: 10.1016/j.snb.2017.10.172
– volume: 261
  start-page: 602
  year: 2018
  ident: D1NR04328E/cit17
  publication-title: Sens. Actuators, B
  doi: 10.1016/j.snb.2018.01.197
– volume: 17
  start-page: 11978
  year: 2011
  ident: D1NR04328E/cit15
  publication-title: Chem. – Eur. J.
  doi: 10.1002/chem.201102060
– volume: 4
  start-page: 781
  year: 2004
  ident: D1NR04328E/cit2
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/nrc1454
– volume: 5
  start-page: 55066
  year: 2015
  ident: D1NR04328E/cit32
  publication-title: RSC Adv.
  doi: 10.1039/C5RA07761C
– volume: 51
  start-page: 1647
  year: 2015
  ident: D1NR04328E/cit45
  publication-title: Chem. Commun.
  doi: 10.1039/C4CC08721F
– volume: 7
  start-page: 4689
  year: 2009
  ident: D1NR04328E/cit31
  publication-title: Org. Biomol. Chem.
  doi: 10.1039/b909682e
– volume: 28
  start-page: 499
  year: 2016
  ident: D1NR04328E/cit33
  publication-title: Supramol. Chem.
  doi: 10.1080/10610278.2015.1125900
– year: 2020
  ident: D1NR04328E/cit42
  publication-title: Supramol. Chem.
  doi: 10.1080/10610278.2020.1857762
– volume: 119
  start-page: 9657
  year: 2019
  ident: D1NR04328E/cit29
  publication-title: Chem. Rev.
  doi: 10.1021/acs.chemrev.8b00605
– volume: 28
  start-page: 492
  year: 2014
  ident: D1NR04328E/cit54
  publication-title: Biomed. Chromatogr.
  doi: 10.1002/bmc.3059
– volume: 978–979
  start-page: 131
  year: 2015
  ident: D1NR04328E/cit7
  publication-title: J. Chromatogr. B: Anal. Technol. Biomed. Life Sci.
  doi: 10.1016/j.jchromb.2014.11.037
– volume: 58
  start-page: 2377
  year: 2019
  ident: D1NR04328E/cit43
  publication-title: Angew. Chem., Int. Ed.
  doi: 10.1002/anie.201813397
– volume: 41
  start-page: 147
  year: 2000
  ident: D1NR04328E/cit56
  publication-title: Adv. Drug Delivery Rev.
  doi: 10.1016/S0169-409X(99)00062-9
– volume: 51
  start-page: 1623
  year: 2019
  ident: D1NR04328E/cit6
  publication-title: Amino Acids
  doi: 10.1007/s00726-019-02799-y
– volume: 4
  start-page: 46
  year: 2020
  ident: D1NR04328E/cit57
  publication-title: Mater. Chem. Front.
  doi: 10.1039/C9QM00489K
– volume: 10
  start-page: 3546
  year: 2019
  ident: D1NR04328E/cit25
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-019-11553-7
– volume: 3
  start-page: 2372
  year: 2013
  ident: D1NR04328E/cit11
  publication-title: Sci. Rep.
  doi: 10.1038/srep02372
– volume: 10
  start-page: 190
  year: 2017
  ident: D1NR04328E/cit46
  publication-title: Macroheterocycles
  doi: 10.6060/mhc170518r
– volume: 111
  start-page: 7941
  year: 2011
  ident: D1NR04328E/cit30
  publication-title: Chem. Rev.
  doi: 10.1021/cr200213s
– volume: 33
  start-page: 115
  year: 1999
  ident: D1NR04328E/cit48
  publication-title: Water Res.
  doi: 10.1016/S0043-1354(98)00170-5
– volume: 52
  start-page: 10648
  year: 2016
  ident: D1NR04328E/cit9
  publication-title: Chem. Commun.
  doi: 10.1039/C6CC05761F
– volume: 55
  start-page: 2340
  year: 2019
  ident: D1NR04328E/cit23
  publication-title: Chem. Commun.
  doi: 10.1039/C8CC09432B
– volume: 15
  start-page: 1649
  year: 2013
  ident: D1NR04328E/cit58
  publication-title: J. Nanopart. Res.
  doi: 10.1007/s11051-013-1649-7
– volume: 18
  start-page: 681
  year: 2018
  ident: D1NR04328E/cit5
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/s41568-018-0050-3
– volume: 281
  start-page: 21799
  year: 2006
  ident: D1NR04328E/cit53
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M602756200
– volume: 54
  start-page: 792
  year: 2015
  ident: D1NR04328E/cit40
  publication-title: Angew. Chem., Int. Ed.
  doi: 10.1002/anie.201407808
– volume: 35
  start-page: 49
  year: 1984
  ident: D1NR04328E/cit47
  publication-title: Chem. Phys. Lipids
  doi: 10.1016/0009-3084(84)90032-X
– volume: 36
  start-page: 78
  year: 2019
  ident: D1NR04328E/cit26
  publication-title: Pharm. Res.
  doi: 10.1007/s11095-019-2608-5
– volume: 178
  start-page: 697
  year: 2018
  ident: D1NR04328E/cit22
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2018.02.051
– volume: 2
  start-page: 318
  year: 2018
  ident: D1NR04328E/cit44
  publication-title: Nat. Biomed. Eng.
  doi: 10.1038/s41551-018-0234-x
– volume: 270
  start-page: 552
  year: 2018
  ident: D1NR04328E/cit13
  publication-title: Sens. Actuators, B
  doi: 10.1016/j.snb.2018.05.050
– volume: 11
  start-page: 28665
  year: 2019
  ident: D1NR04328E/cit24
  publication-title: ACS Appl. Mater. Interfaces
  doi: 10.1021/acsami.9b09059
– volume: 142
  start-page: 557
  year: 1993
  ident: D1NR04328E/cit55
  publication-title: Am. J. Pathol.
– volume: 24
  start-page: 184
  year: 2005
  ident: D1NR04328E/cit4
  publication-title: Clin. Nutr.
  doi: 10.1016/j.clnu.2004.11.001
– volume: 140
  start-page: 3500
  year: 2018
  ident: D1NR04328E/cit28
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/jacs.7b13298
– volume: 162
  start-page: 175
  year: 1993
  ident: D1NR04328E/cit8
  publication-title: J. Immunol. Methods
  doi: 10.1016/0022-1759(93)90382-H
– volume: 10
  start-page: 5365
  year: 2018
  ident: D1NR04328E/cit20
  publication-title: ACS Appl. Mater. Interfaces
  doi: 10.1021/acsami.7b19784
– volume: 66
  start-page: 8
  year: 2014
  ident: D1NR04328E/cit1
  publication-title: Int. Union Biochem. Mol. Biol.
  doi: 10.1002/iub.1237
– volume: 59
  start-page: 1
  year: 2019
  ident: D1NR04328E/cit36
  publication-title: Isr. J. Chem.
  doi: 10.1002/ijch.201900032
– volume: 2
  start-page: 2485
  year: 2020
  ident: D1NR04328E/cit37
  publication-title: CCS Chem.
  doi: 10.31635/ccschem.020.202000124
– volume: 51
  start-page: 6263
  year: 2012
  ident: D1NR04328E/cit52
  publication-title: Biochemistry
  doi: 10.1021/bi300836r
– volume: 280
  start-page: 18
  year: 2019
  ident: D1NR04328E/cit14
  publication-title: J. Mol. Liq.
  doi: 10.1016/j.molliq.2019.01.132
– volume: 8
  start-page: 22780
  year: 2016
  ident: D1NR04328E/cit19
  publication-title: ACS Appl. Mater. Interfaces
  doi: 10.1021/acsami.6b08295
– volume: 34
  start-page: 11220
  year: 2018
  ident: D1NR04328E/cit49
  publication-title: Langmuir
  doi: 10.1021/acs.langmuir.8b00290
– volume: 52
  start-page: 1040
  year: 2016
  ident: D1NR04328E/cit12
  publication-title: Chem. Commun.
  doi: 10.1039/C5CC07861J
– volume: 48
  start-page: 5841
  year: 2012
  ident: D1NR04328E/cit10
  publication-title: Chem. Commun.
  doi: 10.1039/c2cc32228e
SSID ssj0069363
Score 2.4615417
Snippet As an important biomarker, the overexpressed spermine has been widely investigated for cancer diagnosis and treatment. However, bioimaging of spermine in...
SourceID proquest
crossref
rsc
SourceType Aggregation Database
Enrichment Source
Index Database
Publisher
StartPage 15362
SubjectTerms Assembling
Assembly
Biocompatibility
Biomarkers
Cancer
Complexation
Fluorescence
Medical imaging
Title Supramolecular imaging of spermine in cancer cells
URI https://www.proquest.com/docview/2575251346
https://www.proquest.com/docview/2571053540
Volume 13
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3BbpwwELWa5NIeqqZt1G2Tiqq9VCvSBRsMxzTZdNWmWylhFXJCxtgKUmAjdrnk6zM2GIiyh6QXhAZjkN_wPB48Mwh9Iz4mjHuZLbS3inu-ClYGXfaDjIeBR1OhN8jO_dmC_I69uC9Zp6NL1ukhv9sYV_I_qIIMcFVRss9AtusUBHAO-MIREIbjkzC-qG8rVpgCt-O8aEsOybHK_13kTUYQroCtxspFvxraokCsyxVA1EEb5Y03dMZK-7IPETs2PuWr2o7rXptmtRLGeWlf1V0fF9dMO2r-1tesKFg2Pmd3bOhacB21D6KJ_m0YyFXbDTFuauscig0yQ6F4oCp4SIhAqA3bPqLqCVaZTjOnrFRWwED0E5L5CT__l5wuzs6SaBpHW2jHhYUAMNnO0Z-fvy7NbOuHWFfL617LpKDF4Y--74dGR7-S2KpMmRdtTkRv0Ot2HWAdNaDuoheifIteDbJDvkPuQ3itFl5rKS0Dr5WXVgOvpeF9jxan0-h4ZrclLmyOHbK2JZswAnOOqmJPeYqBQT0ONjH3uATypSKUsN6DNhmVLgdjnmBKGM2EFwQsA_NyD22Xy1J8QJbrYCak5FRKQmjop3giQwkiSsAoDtIR-m7GIOFt_ndVhuQm0fsQcJicOPNzPV7TEfratb1tsp5sbLVvhjJpv4pVAlOABzYzJv4IfekuA2epYWClWNa6jaPyCpHJCO0BBN0zesQ-PuHmT-hlr7X7aHtd1eIATMR1-rnVknuan2Pf
linkProvider Royal Society of Chemistry
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Supramolecular+imaging+of+spermine+in+cancer+cells&rft.jtitle=Nanoscale&rft.au=Tian%2C+Han-Wen&rft.au=Chang%2C+Yu-Xuan&rft.au=Hu%2C+Xin-Yue&rft.au=Shah%2C+Muhammad+Raza&rft.date=2021-09-23&rft.issn=2040-3372&rft.eissn=2040-3372&rft.volume=13&rft.issue=36&rft.spage=15362&rft_id=info:doi/10.1039%2Fd1nr04328e&rft.externalDBID=NO_FULL_TEXT
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2040-3364&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2040-3364&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2040-3364&client=summon