Supramolecular imaging of spermine in cancer cells

As an important biomarker, the overexpressed spermine has been widely investigated for cancer diagnosis and treatment. However, bioimaging of spermine in living cells is still a formidable challenge. Herein, we design a supramolecular imaging ensemble for spermine by the host-guest complexation of a...

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Published inNanoscale Vol. 13; no. 36; pp. 15362 - 15368
Main Authors Tian, Han-Wen, Chang, Yu-Xuan, Hu, Xin-Yue, Shah, Muhammad Raza, Li, Hua-Bin, Guo, Dong-Sheng
Format Journal Article
LanguageEnglish
Published Cambridge Royal Society of Chemistry 23.09.2021
Subjects
Assembling
Assembly
Biocompatibility
Biomarkers
Cancer
Complexation
Fluorescence
Medical imaging
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Summary:As an important biomarker, the overexpressed spermine has been widely investigated for cancer diagnosis and treatment. However, bioimaging of spermine in living cells is still a formidable challenge. Herein, we design a supramolecular imaging ensemble for spermine by the host-guest complexation of amphiphilic sulfonatocalix[5]arene (SC5A12C) assembly with lucigenin (LCG). Strong binding ability and complexation-induced fluorescence quenching properties enable SC5A12C to quench the fluorescence of LCG dramatically and to recover it completely due to the competition of overexpressed spermine in cancer cells. SC5A12C also exhibits excellent biocompatibility and promotes cellular uptake due to its ability to form ultra-stable assembly. Co-assembling folate further promotes the cellular uptake of folate receptor overexpressed cancer cells, contributing to enhanced bioimaging. A supramolecular imaging ensemble for spermine is developed by the complexation of amphiphilic sulfonatocalix[5]arene (SC5A12C) assembly with lucigenin.
Bibliography:10.1039/d1nr04328e
Electronic supplementary information (ESI) available. See DOI
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ISSN:2040-3364
2040-3372
2040-3372
DOI:10.1039/d1nr04328e