Association of Disease Activity with Serum and Tear IL-2 Levels in Behçet Disease

• Published in: Ocular immunology and inflammation Vol. 24; no. 3; pp. 313 - 318
• Main Authors: Türkçüoğlu, Peykan, Arat, Yonca Ozkan, Kan, Emrah, Kan, Elif Kılıç, Chaudhry, Imtiaz A., Koca, Süleyman, Çeliker, Ülkü, İlhan, Nevin
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 01.06.2016
• Subjects: Adolescent; Adult; Behcet Syndrome - blood; Behçet; Behçet's disease; Case-Control Studies; Enzyme-Linked Immunosorbent Assay; Eye Proteins - metabolism; Female; Humans; interleukin; interleukin-2; Interleukin-2 - blood; Male; Middle Aged; Prospective Studies; tear interleukin; Tears - metabolism; Young Adult; Behçet; Behçet's disease; interleukin-2; interleukin; tear interleukin
• ISSN: 0927-3948; 1744-5078
• DOI: 10.3109/09273948.2014.1003661

Purpose: To investigate the association of Behçet disease activity with serum and tear interleukin-2 levels. Methods: The study was designed as a prospective case control study. The study population consisted of 45 patients with Behçet disease and 24 age and sex-matched healthy participants. Behçet disease patients were classified as active (24 patients) or inactive (21 patients) according to disease activity. Serum and tear interleukin-2 levels were determined using the enzyme-linked immunosorbent assay method. Results: The mean serum and tear interleukin-2 levels of the active disease, inactive disease, and control groups were 17.04 ± 5.02 and 32.61 ± 16.53 pg/mL; 15.20 ± 4.68 and 29.61 ± 8.30 pg/mL; and 14.22 ± 4.18 and 28.89 ± 8.73 pg/mL, respectively. There was no statistically significant difference between the groups with respect to all measured data. Conclusions: There was no significant difference in serum or tear IL-2 levels between Behçet patients and controls; there was no association of disease activity with serum and tear IL-2 levels.