Water-soluble pillar[6]arene bearing pyrene on alternating methylene bridges for direct spermine sensing

This paper describes the design and synthesis of a conjugate, which is composed of a percarboxylated water-soluble pillar[6]arene and three fluorescent pyrene chromophores on alternating methylene bridges. The optical characteristics are investigated. This conjugate is capable of encapsulating polyc...

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Bibliographic Details
Published inChemical communications (Cambridge, England) Vol. 59; no. 95; pp. 14161 - 14164
Main Authors Ling, Li, Zhao, Zizhen, Mao, Lijun, Wang, Shuyi, Ma, Da
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 28.11.2023
Royal Society of Chemistry
Subjects
Chemistry
Chemistry, Multidisciplinary
Chromophores
Conjugates
Fluorescence
Methylene
Optical properties
Physical Sciences
Science & Technology
Water chemistry
FLUORESCENT SENSOR
HOST
CYCLODEXTRIN
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Summary:This paper describes the design and synthesis of a conjugate, which is composed of a percarboxylated water-soluble pillar[6]arene and three fluorescent pyrene chromophores on alternating methylene bridges. The optical characteristics are investigated. This conjugate is capable of encapsulating polycationic guest spermine, which results in an enhancement in the fluorescence intensity of pyrene. This host-pyrene conjugate is used for direct sensing of spermine, which shows selectivity towards a variety of biological analytes. The detection of spermine is demonstrated in live cells. A pyrene-conjugated water-soluble pillar[6]arene is synthesized and used for direct spermine sensing in live cells.
Bibliography:Electronic supplementary information (ESI) available: General experimental, synthesis, fluorescence analysis, host-guest chemistry, and CLSM method. See DOI
https://doi.org/10.1039/d3cc05094g
ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
ISSN:1359-7345
1364-548X
DOI:10.1039/d3cc05094g