A voltammetric sensor based on a carbon black and chitosan-stabilized gold nanoparticle nanocomposite for ketoconazole determination
A modified glassy carbon electrode with carbon black (CB) and gold nanoparticles (AuNPs) within a crosslinked chitosan (CTS) film is proposed in this work. The electroanalytical performance of the modified CB-CTS-AuNPs/GCE has been evaluated towards the voltammetric sensing of ketoconazole (KTO), a...
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Published in | Analytical methods Vol. 13; no. 38; pp. 4495 - 452 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Cambridge
Royal Society of Chemistry
08.10.2021
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Subjects | |
Online Access | Get full text |
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Summary: | A modified glassy carbon electrode with carbon black (CB) and gold nanoparticles (AuNPs) within a crosslinked chitosan (CTS) film is proposed in this work. The electroanalytical performance of the modified CB-CTS-AuNPs/GCE has been evaluated towards the voltammetric sensing of ketoconazole (KTO), a widespread antifungal drug. The nanocomposite was characterized by scanning electron microscopy, X-ray diffraction spectroscopy, and electrochemistry experiments. The evaluation of the electrochemical behaviour of KTO on the proposed modified electrode shows an irreversible oxidation process at a potential of +0.65 V (
vs.
Ag/AgCl (3.0 mol L
−1
KCl)). This redox process was explored to carry out KTO sensing using square-wave voltammetry. The analytical curve was linear in the KTO concentration range from 0.10 to 2.9 μmol L
−1
, with a limit of detection (LOD) of 4.4 nmol L
−1
and a sensitivity of 3.6 μA L μmol
−1
. This modified electrode was successfully applied to the determination of KTO in pharmaceutical formulations and biological fluid samples.
Exploring chitosan-stabilized gold nanoparticles and carbon black nanoparticles for the sensitive voltammetric sensing of ketoconazole. |
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Bibliography: | 10.1039/d1ay01321a Electronic supplementary information (ESI) available. See DOI ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1759-9660 1759-9679 |
DOI: | 10.1039/d1ay01321a |