Hydrogen-bonded organic frameworks: new horizons in biomedical applications
Hydrogen-bonded organic frameworks (HOFs) are an emerging attractive class of highly crystalline porous materials characterized by significant biocompatibility, rich chemical functionalities and well-defined porosity. The unique advantages including metal-free nature and reversible binding manner si...
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| Published in | Chemical Society reviews Vol. 52; no. 21; pp. 754 - 7523 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Royal Society of Chemistry
30.10.2023
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| Subjects | |
| Online Access | Get full text |
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| Summary: | Hydrogen-bonded organic frameworks (HOFs) are an emerging attractive class of highly crystalline porous materials characterized by significant biocompatibility, rich chemical functionalities and well-defined porosity. The unique advantages including metal-free nature and reversible binding manner significantly distinguish HOFs from other porous materials in the biotechnology and biomedical field. However, the relevant HOF studies still remain in their infancy despite the promising and remarkable results that have been presented in recent years. Due to the intricate and dynamic nature of physiological conditions, the major challenge lies in the stability and structural diversity of HOFs
in vivo
. In this Tutorial Review, we summarize the common building blocks for the construction of HOF-based functional biomaterials and the latest developments in the biological field. Moreover, we highlight current challenges regarding the stability and functionalization of HOFs along with the corresponding potential solutions. This Tutorial Review will have a profound effect in future years on the design and applications of HOF-based biomaterials.
Hydrogen-bonded organic frameworks (HOFs) are an emerging attractive class of highly crystalline porous materials characterized by significant biocompatibility, rich chemical functionalities and well-defined porosity. |
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| Bibliography: | Haochen Zhang received his BS degree from Sichuan University in 2019. Currently, he is pursuing his PhD degree under the supervision of Prof. Xiaogang Qu at Changchun Institute of Applied Chemistry (CAS). His research interests focus on the synthesis and application of hydrogen-bonded organic frameworks and covalent-organic frameworks for the treatment of Alzheimer's disease. Dongqin Yu received her PhD from the Chinese Academy of Sciences (CAS) in 2021. Afterwards, she worked in Changchun Institute of Applied Chemistry (CAS) as an Assistant Professor. Her recent research interests focus on the rational design and synthesis of functional metal-organic frameworks and hydrogen-bonded organic frameworks for Alzheimer's disease treatment. Jinsong Ren received her BSc degree at Nanjing University in 1990, and PhD from the Changchun Institute of Applied Chemistry, Chinese Academy of Sciences in 1995. From 1996 to 2002, she worked in the School of Medicine, UMMC and Department of Chemistry and Chemical Engineering, California Institute of Technology. In 2002, she took a position as a principal investigator at Changchun Institute of Applied Chemistry, Chinese Academy of Sciences. Her current research is mainly focused on drug screening and DNA-based nanofunctional materials. Xiaogang Qu received his PhD from the Chinese Academy of Sciences (CAS) in 1995 with the President's Award of CAS. He moved to the U.S. afterwards and worked with Professor J. B. Chaires at the Mississippi Medical Center and Nobel Laureate Professor Ahmed H. Zewail at the California Institute of Technology. Since late 2002, he has been a professor at the Changchun Institute of Applied Chemistry, CAS. From 12/2006 to 05/2007, he visited the group of Nobel Laureate Professor Alan J. Heeger at UCSB. His current research is focused on ligand nucleic acids and related protein interactions and biofunctional materials for advanced medical technology. ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 |
| ISSN: | 0306-0012 1460-4744 |
| DOI: | 10.1039/d3cs00408b |