PROBLEMS AND PROSPECTS OF INTERMEDIARY METABOLISM CORRECTION IN PATIENTS WITH VASCULAR COMORBIDITY

Disorders of intermediary metabolism in the glycolysis cycles and fatty acids oxidation play a major role in heart and brain lesions of vascular origin. Features of the free-radical processes in various forms of vascular disease are presented. Differences within the free-radical processes reflecting...

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Published inRat͡s︡ionalʹnai͡a︡ farmakoterapii͡a︡ v kardiologii Vol. 9; no. 3; pp. 316 - 322
Main Authors Rumyantseva, S. A., Oganov, R. G., Stupin, V. A., Silina, E. V., Orlova, A. S., Bolevich, S. B., Afanasev, V. V., Kabaeva, E. N., Volik, S. A.
Format Journal Article
LanguageEnglish
Published Столичная издательская компания 01.01.2013
Subjects
acute stroke
beta-oxidation blockers
complex cytoprotection
fatty acids beta-oxidation
ischemic heart disease
myocardial infarction
vascular comorbidity
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Summary:Disorders of intermediary metabolism in the glycolysis cycles and fatty acids oxidation play a major role in heart and brain lesions of vascular origin. Features of the free-radical processes in various forms of vascular disease are presented. Differences within the free-radical processes reflecting the severity of tissue energy deficit are shown in stroke patients with concomitant ischemic heart disease, atrial fibrillation, and diabetes mellitus. Various aspects of the treatment of patients with vascular comorbidity are presented with the focus on correction of intermediary metabolism disorders. Complex energy correcting therapy including beta-oxidation blocker (meldonium) is discussed.
ISSN:1819-6446
2225-3653
DOI:10.20996/1819-6446-2013-9-3-316-322