Management of Multidrug-Resistant CMV Infection in Immunocompromised Patients: Case Report of a Heart-Transplant Recipient and Review of the Literature

Cytomegalovirus (CMV) remains a leading cause of morbidity after solid organ transplantation. The efficiency of antivirals for the treatment of CMV infections may be hampered because of the emergence of CMV resistance to antivirals. The development of CMV multidrug resistance, which remains uncommon...

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Bibliographic Details
Published inAntiviral therapy Vol. 20; no. 2; pp. 249 - 254
Main Authors Deback, Claire, Burrel, Sonia, Varnous, Shaïda, Carcelain, Guislaine, Conan, Françoise, Aït-Arkoub, Zaïna, Autran, Brigitte, Gandjbakhch, Iradj, Agut, Henri, Boutolleau, David
Format Journal Article
LanguageEnglish
Published England 01.01.2015
Subjects
Adrenal Cortex Hormones - therapeutic use
Adult
Aged
Antiviral Agents - therapeutic use
Cyclosporine - therapeutic use
Cytomegalovirus - drug effects
Cytomegalovirus - physiology
Cytomegalovirus Infections - drug therapy
Cytomegalovirus Infections - etiology
Cytomegalovirus Infections - immunology
Cytomegalovirus Infections - virology
Disease Management
Drug Resistance, Viral
Everolimus - therapeutic use
Female
Foscarnet - therapeutic use
Ganciclovir - analogs & derivatives
Ganciclovir - therapeutic use
Heart Transplantation - adverse effects
Herpesviridae
Humans
Immunocompromised Host
Immunosuppressive Agents - therapeutic use
Infant
Male
Middle Aged
Viral Load - drug effects
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Summary:Cytomegalovirus (CMV) remains a leading cause of morbidity after solid organ transplantation. The efficiency of antivirals for the treatment of CMV infections may be hampered because of the emergence of CMV resistance to antivirals. The development of CMV multidrug resistance, which remains uncommon but does occur, constitutes a clinically challenging complication and may contribute to difficult therapeutic management and adverse clinical outcome. We report here the observation of the emergence of a multidrug-resistant CMV infection in a heart-transplant recipient and review the literature on similar cases to identify the potential strategies for the successful management of CMV multidrug resistance among immunocompromised patients.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Review-5
ObjectType-Feature-4
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ObjectType-Report-1
ObjectType-Article-3
ObjectType-Article-1
ObjectType-Feature-2
ISSN:1359-6535
2040-2058
2040-2058
DOI:10.3851/IMP2818