Rhodium-catalyzed C-H activation/cyclization of aryl sulfoximines with iodonium ylides towards polycyclic 1,2-benzothiazines

The synthesis of 1,2-benzothiazine derivatives through rhodium-catalyzed C-H activation/cyclization of S -aryl sulfoximines with iodonium ylides was developed for the first time. In this report, C-H and N-H bond functionalization was realized towards a series of tricyclic and tetracyclic sulfoximine...

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Published inOrganic & biomolecular chemistry Vol. 19; no. 46; pp. 185 - 189
Main Authors Huang, Gao, Shan, Yujia, Yu, Jin-Tao, Pan, Changduo
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 01.12.2021
Royal Society of Chemistry
Subjects
Aromatic compounds
Catalysis
Chemistry
Chemistry, Organic
Hydrogen bonds
Physical Sciences
Rhodium
Science & Technology
FUNCTIONALIZATION
KETONES
ACTIVATION
INSERTION
OXIDATIVE ANNULATION
INDOLES
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Summary:The synthesis of 1,2-benzothiazine derivatives through rhodium-catalyzed C-H activation/cyclization of S -aryl sulfoximines with iodonium ylides was developed for the first time. In this report, C-H and N-H bond functionalization was realized towards a series of tricyclic and tetracyclic sulfoximine derivatives with moderate to excellent yields under simple reaction conditions. The synthesis of polycyclic 1,2-benzothiazines through rhodium-catalyzed C-H activation/cyclization of S -aryl sulfoximines with iodonium ylides has been developed for the first time.
Bibliography:10.1039/d1ob02052h
Electronic supplementary information (ESI) available. See DOI
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1477-0520
1477-0539
DOI:10.1039/d1ob02052h