Pro-atrial natriuretic peptide hormone from right atria is correlated with cardiac depression in septic patients

• Published in: Journal of endocrinological investigation Vol. 24; no. 7; pp. RC22 - RC24
• Main Authors: MAZUL-SUNKO, B, ZARKOVIC, N, VRKIC, N, KLINGER, R, PERIC, M, BEKAVAC-BESLIN, M, NOVKOSKI, M, KRIZMANIC, A, GVOZDENOVIC, A, TOPIC, E
• Format: Journal Article
• Language: English
• Published: Milano Kurtis 01.07.2001
• Subjects: Acidosis - physiopathology; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Animals; Biological and medical sciences; Blood Gas Analysis; Blood Pressure - physiology; Cardiac Output - physiology; Dogs; Emergency and intensive care: infection, septic shock; Female; Hemodynamics - physiology; Hypoxia - physiopathology; Intensive care medicine; Male; Medical sciences; Pulmonary Circulation - physiology; Thermodilution; Ventricular Function, Right - physiology; Human; Heart failure; Respiratory disease; Acute; Biological marker; Cardiovascular disease; Atrial natriuretic peptide; Prohormone; Blood plasma; Infection; Sepsis syndrome; Natriuretic hormone; Heart disease; Complication; Respiratory distress; Predictive factor
• ISSN: 0391-4097; 1720-8386
• DOI: 10.1007/BF03343878

N-terminal pro-atrial natriuretic peptide [proANP(1-98)] has been extensively investigated in patients with chronic heart failure and ishemic heart disease. It is found to be a better marker of cardiac dysfunction than atrial natriuretic peptide (ANP). The possible involvement of proANP(1-98) in cardiac depression caused by sepsis has not been studied yet. Therefore, we analyzed atrial plasma concentration of proANP(1-98) in 17 septic patients with hemodynamic variables measured or calculated using pulmonary artery catheter. The results of altogether 96 measurements show a significant negative correlation of proANP(1-98) and cardiac index (p<0.024), oxygen delivery (p<0.03) and oxygen consumption (p<0.03). There is also a positive correlation with pulmonary vascular resistance (p<0.03). ProANP(1-98) is significantly higher in patients who developed acute respiratory distress syndrome (ARDS) (p<0.001). This study implies that proANP(1-98) is a possible novel hormone marker of cardiac depression caused by sepsis that could be used for prediction of ARDS.