Blood-brain barrier (BBB)-on-a-chip: a promising breakthrough in brain disease research
The blood-brain barrier (BBB) represents a key challenge in developing brain-penetrating therapeutic molecules. BBB dysfunction is also associated with the onset and progression of various brain diseases. The BBB-on-a-chip (μBBB), an organ-on-chip technology, has emerged as a powerful in vitro platf...
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| Published in | Lab on a chip Vol. 22; no. 19; pp. 3579 - 362 |
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| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Cambridge
Royal Society of Chemistry
27.09.2022
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| Subjects | |
| Online Access | Get full text |
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| Summary: | The blood-brain barrier (BBB) represents a key challenge in developing brain-penetrating therapeutic molecules. BBB dysfunction is also associated with the onset and progression of various brain diseases. The BBB-on-a-chip (μBBB), an organ-on-chip technology, has emerged as a powerful
in vitro
platform that closely mimics the human BBB microenvironments. While the μBBB technology has seen wide application in the study of brain cancer, its utility in other brain disease models ("μBBB+") is less appreciated. Based on the advances of the μBBB technology and the evolution of
in vitro
models for brain diseases over the last decade, we propose the concept of a "μBBB+" system and summarize its major promising applications in pathological studies, personalized medical research, drug development, and multi-organ-on-chip approaches. We believe that such a sophisticated "μBBB+" system is a highly tunable and promising
in vitro
platform for further advancement of the understanding of brain diseases.
This review summarizes recent advances of the integration between BBB-on-a-chip (μBBB) technology and brain disease modeling. It provides a guideline to extend their applications in pathological research, drug development, and personalized medicine. |
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| Bibliography: | Prof. Lin Li received his BSc and PhD in Chemistry from Anhui University in 2004 and 2009, respectively. He carried out postdoctoral studies with Professor Shao Q. Yao at NUS. He obtained his current Professor position at Nanjing Tech University in 2015. His research group focuses on synthetic small-molecule indicators for monitoring biological/chemical species in physiological environments. Shiping Hao received his B.Eng degree from Taiyuan University of Technology (China) in 2020. Currently, he is studying as a Master's student at Northwestern Polytechnical University (China). His research interests focus on organ-on-a-chip and its applications in brain diseases. Dr. Ziqiu Tong received his Bachelor's degree in Chemical Engineering from the City College of City University of New York in 2006. He completed his PhD in 2011 at the Johns Hopkins University in Baltimore, USA. From 2012 till 2014, Dr. Tong was a post-doctoral fellow at the Institute for Bioengineering of Catalonia, Barcelona, Spain. He then worked as a research associate at the Future Industry Institute at the University of South Australia, Australia from 2015 to 2017. Since then, he has been working at the Monash University as a research fellow. Nicolas Voelcker received his BSc from the University of Saarland (1993), his MSc from the RWTH Aachen (1995) and his PhD degree (1999) from the DWI Leibniz Institute. He received postdoctoral fellowships at the Scripps Research Institute in La Jolla. In 2001, he became a Lecturer at Flinders University, an Associate Professor in 2006 and a full Professor in 2008. He was a Professor at the University of South Australia (2012-2017). Since 2017, he has been the Scientific Director of the Melbourne Centre for Nanofabrication, a Professor at Monash University and a Science Leader at the Commonwealth Scientific and Industrial Research Organisation (CSIRO). Dr. Bo Peng received his BSc degree in Clinical Pharmacy (2011) from Huazhong University of Science and Technology, his MRes degree from UCL (2012) and his PhD degree in Chemical Biology (2017) from NUS under the supervision of Professor Shao Q. Yao. In 2017 he joined the research group of Professor Nicolas Voelcker as a postdoctoral research fellow at CSIRO. Currently he is an Associate Professor at Northwestern Polytechnical University. His research interests focus on the applications of Chemical Biology to lab-on-a-chip platforms and nanomedicine. Prof. Wei Huang received his PhD degree from Peking University (1992). He began his postdoctoral research at the National University of Singapore (NUS, 1993), moved to Fudan University where he founded the Institute of Advanced Materials (IAM, 2002), was appointed as the Deputy President of Nanjing University of Posts and Telecommunications (NJUPT, 2006), and was elected as Academician of the Chinese Academy of Sciences (CAS) in 2011. He assumed his duty as the President of Nanjing Tech University (NanjingTech, 2012) and was appointed as the Deputy President & Provost of Northwestern Polytechnical University (NPU, 2017). His research interests include organic/flexible electronics, nanomaterials and nanotechnology. ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 |
| ISSN: | 1473-0197 1473-0189 |
| DOI: | 10.1039/d2lc00305h |