From proteomic landscape to single-cell oncoproteomics

: Proteomic profiling plays an important role in the exploration of cancer from molecular mechanisms to clinical diagnosis and treatment. In recent years, the advent of new technologies has promoted oncoproteomics from the initial global style to a refined single-cell level. : Among them, the develo...

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Bibliographic Details
Published inExpert review of proteomics Vol. 18; no. 1; p. 1
Main Authors Xue, Vivian Weiwen, Wong, Sze Chuen Cesar, Cho, William Chi
Format Journal Article
LanguageEnglish
Published England 02.01.2021
Subjects
Humans
Mass Spectrometry
Neoplasms - chemistry
Neoplasms - metabolism
Proteome - analysis
Proteome - chemistry
Proteomics
Single-Cell Analysis
single-cell western blotting
mass spectrometry
single-cell mass cytometry
single-cell oncoproteomics
Proteomic profiling
protein sequencing
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Summary:: Proteomic profiling plays an important role in the exploration of cancer from molecular mechanisms to clinical diagnosis and treatment. In recent years, the advent of new technologies has promoted oncoproteomics from the initial global style to a refined single-cell level. : Among them, the development of microfluidic devices, the improvement of liquid mass spectrometry in accuracy and trace sample handling processes, and the emergence of protein sequencing have contributed to the oncoproteomic analysis at the single-cell level. : The proteomic analysis at the global level and the single-cell level gives different perspectives while combining them can reveal more comprehensive oncoproteomics and help cancer research and treatment strategies.
ISSN:1744-8387
DOI:10.1080/14789450.2021.1890036