Cell surface-localized imaging and sensing

Systematically dissecting the molecular basis of the cell surface as well as its related biological activities is considered as one of the most cutting-edge fields in fundamental sciences. The advent of various advanced cell imaging techniques allows us to gain a glimpse of how the cell surface is s...

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Published inChemical Society reviews Vol. 5; no. 1; pp. 624 - 6277
Main Authors Jia, Hao-Ran, Zhu, Ya-Xuan, Duan, Qiu-Yi, Wu, Fu-Gen
Format Journal Article
LanguageEnglish
Published London Royal Society of Chemistry 24.05.2021
Subjects
Biomedical materials
Cellular structure
Chemists
Imaging
Imaging techniques
Surface properties
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Summary:Systematically dissecting the molecular basis of the cell surface as well as its related biological activities is considered as one of the most cutting-edge fields in fundamental sciences. The advent of various advanced cell imaging techniques allows us to gain a glimpse of how the cell surface is structured and coordinated with other cellular components to respond to intracellular signals and environmental stimuli. Nowadays, cell surface-related studies have entered a new era featured by a redirected aim of not just understanding but artificially manipulating/remodeling the cell surface properties. To meet this goal, biologists and chemists are intensely engaged in developing more maneuverable cell surface labeling strategies by exploiting the cell's intrinsic biosynthetic machinery or direct chemical/physical binding methods for imaging, sensing, and biomedical applications. In this review, we summarize the recent advances that focus on the visualization of various cell surface structures/dynamics and accurate monitoring of the microenvironment of the cell surface. Future challenges and opportunities in these fields are discussed, and the importance of cell surface-based studies is highlighted. We present a comprehensive review on the advancements in cell surface modification strategies and their applications in cell surface-localized imaging and sensing.
Bibliography:Ya-Xuan Zhu received her BS degree from the Southeast University in 2016, and currently is pursuing her PhD degree under the supervision of Prof. Fu-Gen Wu at the School of Biological Sciences and Medical Engineering, the Southeast University. Her research interests are therapeutic nanomaterials and cell surface functionalization.
Dr Fu-Gen Wu is a professor of Biomedical Engineering at the Southeast University, Nanjing, China. He obtained his BS and PhD degrees from Tsinghua University in 2006 and 2011, respectively. After a postdoctoral period at the University of Michigan-Ann Arbor, he joined the Southeast University in 2013 and was promoted to be a professor. His main research interests are fluorescence imaging, chemical biology, and bionanomaterials.
Qiu-Yi Duan received her BS degree from the Southeast University in 2020. She is currently pursuing her master's degree under the guidance of Prof. Fu-Gen Wu at the School of Biological Science and Medical Engineering, the Southeast University. Her research focuses on nanomaterials for anticancer treatment.
Hao-Ran Jia received his BS degree in biomedical engineering from Southeast University in 2015. He is now pursuing his PhD degree under the guidance of Prof. Fu-Gen Wu at School of Biological Sciences and Medical Engineering, Southeast University. The main interest of his research is cell surface engineering and therapeutic nanomaterials for anticancer and antimicrobial applications.
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ISSN:0306-0012
1460-4744
DOI:10.1039/d1cs00067e