A novel distyryl boron dipyrromethene with two functional tags for site-specific bioorthogonal photosensitisation towards targeted photodynamic therapy

A distyryl boron dipyrromethene based photosensitiser substituted with 1,2,4,5-tetrazine and alkyne moieties was prepared. Through site-specific bioorthogonal reactions with the complementary functional tags anchored on the membrane of A431 human epidermoid carcinoma cells, this versatile photosensi...

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Published inChemical communications (Cambridge, England) Vol. 55; no. 9; pp. 13518 - 13521
Main Authors Guo, Xuejiao, Wong, Roy C. H, Zhou, Yimin, Ng, Dennis K. P, Lo, Pui-Chi
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 07.11.2019
Royal Society of Chemistry
Subjects
Alkynes
Boron
Chemistry
Chemistry, Multidisciplinary
Photodynamic therapy
Physical Sciences
Science & Technology
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STRATEGIES
PROBES
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Summary:A distyryl boron dipyrromethene based photosensitiser substituted with 1,2,4,5-tetrazine and alkyne moieties was prepared. Through site-specific bioorthogonal reactions with the complementary functional tags anchored on the membrane of A431 human epidermoid carcinoma cells, this versatile photosensitiser exhibited enhanced cellular uptake and photocytotoxicity. The bioorthogonal ligation was also demonstrated in tumour-bearing nude mice. A sequential "tag-and-click" process for targeted delivery of photosensitisers for photodynamic therapy.
Bibliography:Electronic supplementary information (ESI) available: Experimental details, characterisation data and additional confocal microscopic images. See DOI
10.1039/c9cc07460k
ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1359-7345
1364-548X
DOI:10.1039/c9cc07460k