Thermally induced silane dehydrocoupling on porous silicon nanoparticles for ultra-long-acting drug release

Here, we report an ultra-long-acting drug release nano-formulation based on porous silicon nanoparticles (pSiNPs) that are prepared by thermally induced silane dehydrocoupling and lipid-coating. This robust formulation offers the ability to release an anticancer drug, for up to 2 weeks, in various b...

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Published inNanoscale Vol. 13; no. 37; pp. 1556 - 15568
Main Authors Oh, Ji Hyeon, Kang, Rae Hyung, Kim, Jaehoon, Bang, Eun-Kyoung, Kim, Dokyoung
Format Journal Article
LanguageEnglish
Published Cambridge Royal Society of Chemistry 01.10.2021
Subjects
Lipids
Nanoparticles
Porous silicon
Silanes
Xenotransplantation
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Summary:Here, we report an ultra-long-acting drug release nano-formulation based on porous silicon nanoparticles (pSiNPs) that are prepared by thermally induced silane dehydrocoupling and lipid-coating. This robust formulation offers the ability to release an anticancer drug, for up to 2 weeks, in various biological environments; pH 7.4 buffer, cancer cells, and tumor xenograft model. An ultra-long-acting drug-releasable (>2 weeks) nano-formulation based on porous silicon nanoparticles (pSiNPs) that are prepared using the thermally induced silane dehydrocoupling, an amphiphilic lipid-coating, and is disclosed for the first time.
Bibliography:10.1039/d1nr03263a
Prof. Dokyoung Kim received his Ph.D. from the Department of Chemistry at POSTECH (Pohang University of Science and Technology) in 2014. After a post-doctoral stay at the University of California, San Diego (2015-2017), he started his independent career at Kyung Hee University, College of Medicine, Seoul. He has been interested in the biomedical applications of nanomaterials.
Electronic supplementary information (ESI) available. See DOI
ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:2040-3364
2040-3372
DOI:10.1039/d1nr03263a