PARTICLE-COLLISION AND POROGEN-LEACHING TECHNIQUE TO FABRICATE POLYMERIC POROUS SCAFFOLDS WITH MICROSCALE ROUGHNESS OF INTERIOR SURFACES

A facile technique is herein reported to fabricate three-dimensional （3D） polymeric porous scaffolds with interior surfaces of a topographic microstructure favorable for cell adhesion. As demonstration, a well-known biodegradable polymer poly（lactide-co-glycolide） （PLGA） was employed as matrix. Unde...

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Bibliographic Details
Published inChinese journal of polymer science Vol. 31; no. 5; pp. 737 - 747
Main Authors Pan, Zhen, Qu, Ze-hua, Zhang, Zheng, Peng, Rong, Yan, Ce, Ding, Jian-dong
Format Journal Article
LanguageEnglish
Published Heidelberg Chinese Chemical Society and Institute of Chemistry, CAS 01.05.2013
Subjects
Characterization and Evaluation of Materials
Chemistry
Chemistry and Materials Science
Condensed Matter Physics
Industrial Chemistry/Chemical Engineering
Polymer Sciences
制作
可生物降解聚合物
多孔支架
浸出技术
粒子碰撞
致孔剂
表面粗糙度
骨髓基质干细胞
Poly(lactide
glycolide) (PLGA
Porous scaffolds
Surface topography
Tissue engineering
Cell adhesion
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Summary:A facile technique is herein reported to fabricate three-dimensional （3D） polymeric porous scaffolds with interior surfaces of a topographic microstructure favorable for cell adhesion. As demonstration, a well-known biodegradable polymer poly（lactide-co-glycolide） （PLGA） was employed as matrix. Under the porogen-leaching strategy, the large and soft porogens of paraffin were modified by colliding with small and hard salt particles, which generated micropits on the surfaces of paraffin spheres. The eventual PLGA scaffolds after leaching the modified porogens had thus interior surfaces of microscale roughness imprinted by those micropits. The microrough scaffolds were confirmed to benefit adhesion of bone marrow stromal cells （BMSCs） of rats and meanwhile not to hamper the proliferation and osteogenic differentiation of the cells. The insight and technique might be helpful for biomaterial designing in tissue engineering and regenerative medicine.
Bibliography:Tissue engineering; Porous scaffolds; Surface topography; Cell adhesion; Poly（lactide-co-glycolide） （PLGA）.
A facile technique is herein reported to fabricate three-dimensional （3D） polymeric porous scaffolds with interior surfaces of a topographic microstructure favorable for cell adhesion. As demonstration, a well-known biodegradable polymer poly（lactide-co-glycolide） （PLGA） was employed as matrix. Under the porogen-leaching strategy, the large and soft porogens of paraffin were modified by colliding with small and hard salt particles, which generated micropits on the surfaces of paraffin spheres. The eventual PLGA scaffolds after leaching the modified porogens had thus interior surfaces of microscale roughness imprinted by those micropits. The microrough scaffolds were confirmed to benefit adhesion of bone marrow stromal cells （BMSCs） of rats and meanwhile not to hamper the proliferation and osteogenic differentiation of the cells. The insight and technique might be helpful for biomaterial designing in tissue engineering and regenerative medicine.
11-2015/O6
ISSN:0256-7679
1439-6203
DOI:10.1007/s10118-013-1264-1