CEA immunohistochemical localization is correlated with growth and metastasis of human gallbladder carcinoma

Carcinoembryonic antigen (CEA) is a good marker of colorectal cancer. Recent studies have demonstrated that CEA may function as a metastatic potentiator by different pathways; i.e., modulation of immune responses, facilitation of intercellular adhesion and cellular migration. However, expression pat...

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Published inInternational journal of oncology Vol. 16; no. 1; p. 49
Main Authors Dowaki, S, Kijima, H, Kashiwagi, H, Ohtani, Y, Tobita, K, Tsukui, M, Tanaka, Y, Tazawa, K, Matsubayashi, H, Tsuchida, T, Nakamura, M, Ueyama, Y, Tanaka, M, Tajima, T, Makuuchi, H
Format Journal Article
LanguageEnglish
Published Greece 01.01.2000
Subjects
Adenocarcinoma - metabolism
Adenocarcinoma - pathology
Adenocarcinoma - secondary
Adult
Aged
Aged, 80 and over
Carcinoembryonic Antigen - analysis
Female
Gallbladder Neoplasms - metabolism
Gallbladder Neoplasms - pathology
Humans
Immunoenzyme Techniques
Male
Middle Aged
Neoplasm Metastasis
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Summary:Carcinoembryonic antigen (CEA) is a good marker of colorectal cancer. Recent studies have demonstrated that CEA may function as a metastatic potentiator by different pathways; i.e., modulation of immune responses, facilitation of intercellular adhesion and cellular migration. However, expression patterns of CEA have not yet been established in human gallbladder carcinomas. In this study, we examined CEA expression in human gallbladder adenocarcinomas and its clinicopathological significance. CEA immunoreactivity was detected not only in the cancer cells (cytoplasmic type: 63.0%, 34/54) but also in the cancer stroma (stromal type: 29.6%, 16/54). According to TNM classification, 75.0% (30/40) of T2-4 gallbladder cancers showed cytoplasmic CEA, while 28.6% (4/14) of the T1 cancers were cytoplasmic CEA-positive (p<0.05). Stromal CEA expression was detected in 40.0% (16/40) and none (0/14) of the T2-4 and T1 cancers, respectively (p<0.05). Lymph node metastasis was frequently found in the cytoplasmic CEA- and stromal CEA-positive gallbladder cancers (44.1% and 62.5%, respectively). These observations suggested that CEA expression plays important roles in cancer cell growth and metastasis of human gallbladder adenocarcinomas.
ISSN:1019-6439
DOI:10.3892/ijo.16.1.49