Promoting neurite outgrowth and neural stem cell migration using aligned nanofibers decorated with protrusions and galectin-1 coating

Biomaterials integrated with both topological cues and biological modifications are urgently needed in regenerative medicine. Here, aligned nanofibrous scaffolds decorated with nanoscale SiO 2 protrusions and galectin-1 coating are reported. Prospects in neurite outgrowth and neural stem cell migrat...

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Published inChemical communications (Cambridge, England) Vol. 59; no. 72; pp. 1753 - 1756
Main Authors Liu, Yingnan, Zhang, Xiaopei, Wang, Yawen, Guo, Mingxia, Sheng, Junyue, Wang, Yuanfei, Wu, Tong
Format Journal Article
LanguageEnglish
Published Cambridge Royal Society of Chemistry 07.09.2023
Subjects
Biomedical materials
Silicon dioxide
Stem cells
Tissue engineering
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Summary:Biomaterials integrated with both topological cues and biological modifications are urgently needed in regenerative medicine. Here, aligned nanofibrous scaffolds decorated with nanoscale SiO 2 protrusions and galectin-1 coating are reported. Prospects in neurite outgrowth and neural stem cell migration are discussed for suitable use in neural tissue engineering. Synergistic effects : owing to the topographic guidance provided by fiber alignment and nanoscale SiO 2 protrusions together with the biological cue of galectin-1 coating, neurite extension and neural stem cell migration were facilitated.
Bibliography:NPs per unit area (μm
2
NPs, FT-IR spectra and water contact angle assay, the largest length of extended neurites from the cells after culturing on the different groups, effects of Gal-1 on cell viability, and the SEM images of radially aligned PCL/SiO
https://doi.org/10.1039/d3cc02869k
Gal-1 nanofibers. See DOI
Electronic supplementary information (ESI) available: Full experimental details, including experimental protocols, EDS analysis, the density of SiO
and the distance between adjacent SiO
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1359-7345
1364-548X
DOI:10.1039/d3cc02869k