Synthesis and studies of 1,2 dihydroquinoline derivatives as inhibitors of lipid peroxidation

• Published in: Arzneimittel-Forschung Vol. 53; no. 10; pp. 722 - 729
• Main Authors: Barta-Szalai, G, Gere, A, Takacs-Novak, K, Domany, G
• Format: Journal Article
• Language: English
• Published: STUTTGART Thieme Medical Publishers 01.01.2003
• Subjects: Animals; Brain Chemistry - drug effects; Chemical Phenomena; Chemistry; Chemistry, Medicinal; Chemistry, Multidisciplinary; Chemistry, Physical; In Vitro Techniques; Indicators and Reagents; Iron - pharmacology; Life Sciences & Biomedicine; Lipid Peroxidation - drug effects; Magnetic Resonance Spectroscopy; Male; Microsomes - drug effects; Microsomes - metabolism; NADP - pharmacology; Naphthalenes - chemical synthesis; Naphthalenes - pharmacology; Pharmacology & Pharmacy; Physical Sciences; Piperidines - chemical synthesis; Piperidines - pharmacology; Quinolines - chemical synthesis; Quinolines - pharmacology; Rats; Rats, Wistar; Science & Technology; Spiro Compounds - chemical synthesis; Spiro Compounds - pharmacology; Structure-Activity Relationship; lipid peroxidation, inhibitors; spiro [naphtho[2,1-c][2,7]naphtiridine-5,4 '-piperidine]-derivatives, inhibition of lipid, peroxidation, synthesis; PARTITION-COEFFICIENTS; antioxidants; LIPOPHILICITY
• ISSN: 0004-4172; 1616-7066
• DOI: 10.1055/s-0031-1299818

A series of new spiro [naphto[2,1-c][2,7]naphtiridine-5,4'-piperidine] derivatives was prepared. Biochemical investigations revealed that all members of this series were potent inhibitors of both NADPH- and Fe2+-dependent lipid peroxidation (IC50 < 10 mumol/l) in rat brain microsomes and rat brain homogenate, respectively.