The Effect of Sugammadex on Prothrombin and Activated Partial Thromboplastin Time

Sugammadex is routinely used as an effective neuromuscular blockade reversal agent. Several studies have indicated that it may prolong the prothrombin time (PT) and the activated partial thromboplastin time (aPTT). This review gathers the relevant studies to accumulate knowledge on the subject. Nine...

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Published inCurēus (Palo Alto, CA) Vol. 13; no. 4; p. e14521
Main Authors Samara, Evangelia, Stamatiou, Konstantinos, Balanika, Marina, Tzimas, Petros
Format Journal Article
LanguageEnglish
Published United States Cureus 16.04.2021
Subjects
Anesthesiology
bleeding
hemostasis
sugammadex
coagulation
prothrombin time (pt)
activated partial thromboplastin time (aptt)
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Summary:Sugammadex is routinely used as an effective neuromuscular blockade reversal agent. Several studies have indicated that it may prolong the prothrombin time (PT) and the activated partial thromboplastin time (aPTT). This review gathers the relevant studies to accumulate knowledge on the subject. Nine studies were included. According to the results, sugammadex seems to lead to a transient increase in aPTT and PT values, compared to standard care. However, the clinical impact seems to be trivial. Nevertheless, the trials' findings reveal great heterogeneity, preventing a meta-analysis. Therefore, more well-designed studies are needed to lead to prudent conclusions.
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ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.14521