Rationally designed Ru() metallacycles with tunable imidazole ligands for synergistical chemo-phototherapy of cancer

Herein, we construct a series of Ru( ii ) metallacycles with multimodal chemo-phototherapeutic properties, which exhibited much higher anticancer activity and better cancer-cell selectivity than cisplatin. The antitumor mechanism could be ascribed to the activation of caspase 3/7 and the resulting a...

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Published inChemical communications (Cambridge, England) Vol. 58; no. 65; pp. 968 - 971
Main Authors Tu, Le, Li, Chonglu, Liu, Chang, Bai, Suya, Yang, Jingfang, Zhang, Xian, Xu, Liying, Xiong, Xiaoxing, Sun, Yao
Format Journal Article
LanguageEnglish
Published Cambridge Royal Society of Chemistry 11.08.2022
Subjects
Anticancer properties
Apoptosis
Imidazole
Organometallic compounds
Selectivity
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Summary:Herein, we construct a series of Ru( ii ) metallacycles with multimodal chemo-phototherapeutic properties, which exhibited much higher anticancer activity and better cancer-cell selectivity than cisplatin. The antitumor mechanism could be ascribed to the activation of caspase 3/7 and the resulting apoptosis. These results open new possibilities for Ru( ii ) metallacycles in biomedicine. Herein, we construct a series of Ru( ii ) metallacycles with multimodal chemo-phototherapeutic properties, which exhibited much higher anticancer activity and better cancer-cell selectivity than cisplatin.
Bibliography:https://doi.org/10.1039/d2cc03118c
Electronic supplementary information (ESI) available. See DOI
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1359-7345
1364-548X
DOI:10.1039/d2cc03118c