Natural epoxyquinoids: isolation, biological activity and synthesis. An update

Epoxyquinoids are of continuing interest due to their wide natural distribution and diverse biological activities, including, but not limited to, antibacterial, antifungal, anticancer, enzyme inhibitory, and others. The last review on their total synthesis was published in 2017. Since then, almost 1...

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Published inOrganic & biomolecular chemistry Vol. 21; no. 41; pp. 8215 - 8243
Main Authors Shcherbinin, Vitaly A, Nasibullina, Ekaterina R, Mendogralo, Elena Y, Uchuskin, Maxim G
Format Journal Article
LanguageEnglish
Published Cambridge Royal Society of Chemistry 25.10.2023
Subjects
Biological activity
Enantiomers
Fungicides
Reviews
Synthesis
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Summary:Epoxyquinoids are of continuing interest due to their wide natural distribution and diverse biological activities, including, but not limited to, antibacterial, antifungal, anticancer, enzyme inhibitory, and others. The last review on their total synthesis was published in 2017. Since then, almost 100 articles have been published on their isolation from nature and their biological profile. In addition, the review specifically considers synthesis, including total and enantioselective, as well as the development of shorter approaches for the construction of epoxyquinoids with complex chemical architecture. Thus, this review focuses on progress in this area in order to stimulate further research. This review provides an updated outlook on the isolation of epoxyquinoids and an examination of their biological profile. Total, enantioselective synthesis, and the development of shorter approaches to construction of epoxyquinoids are addressed.
Bibliography:ObjectType-Article-2
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ISSN:1477-0520
1477-0539
DOI:10.1039/d3ob01141k