Canine Distemper Virus in Domesticated Cats and Pigs

• Published in: Advances in enzymology and related subjects Vol. 35; no. 6; pp. 803 - 806
• Main Authors: Appel, M., Sheffy, B. E., Percy, D. H., Gaskin, J. M.
• Format: Journal Article
• Language: English
• Published: United States 01.01.1974
• Subjects: Administration, Intranasal; animal diseases; animal health; Animals; Animals, Newborn; Brain; Cat Diseases - etiology; Cat Diseases - immunology; Cat Diseases - pathology; Cats; Cells, Cultured; Distemper - immunology; Distemper - pathology; Distemper Virus, Canine - growth & development; Distemper Virus, Canine - immunology; Distemper Virus, Canine - pathogenicity; Dogs; Fluorescent Antibody Technique; Injections; Lung; Macrophages; Neutralization Tests; Swine; Swine Diseases - etiology; Swine Diseases - immunology; Swine Diseases - pathology; Thymus Gland - pathology
• ISSN: 0002-9645; 0065-258X
• DOI: 10.2460/ajvr.1974.35.06.803

Twenty-two cats and 17 pigs, ranging in age from 2 days to 2 years, were found to be susceptible to intranasal inoculation of virulent canine distemper ( cd ) virus. Virus replicated in lymphatic tissues and in macrophages, but not in surface epithelium or brain. Infection with cd virus in cats and pigs was inapparent. Pathologic changes were mild and were restricted to lymphatic tissue and lungs. Intracerebral inoculation did not result in clinical signs or pathologic changes in the brain. Virus spread from infected dogs to cats, but not from infected cats to dogs, cats to cats, or pigs to pigs. Serum samples from 14 of 150 cats had neutralizing antibody to cd virus.