Light-activated gene expression from site-specific caged DNA with a biotinylated photolabile protection group

A new method for site-specific caging of plasmid DNA was developed to enable light-activation of gene expression in living cells by exposure to a low dose of light.

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Bibliographic Details
Published inChemical communications (Cambridge, England) Vol. 46; no. 13; pp. 2244 - 2246
Main Authors Yamaguchi, Satoshi, Chen, Yanjie, Nakajima, Soh, Furuta, Toshiaki, Nagamune, Teruyuki
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 01.01.2010
Subjects
Biotin - chemistry
Biotin - metabolism
Chemistry
Chemistry, Multidisciplinary
DNA - metabolism
Gene Expression
Green Fluorescent Proteins - genetics
Green Fluorescent Proteins - metabolism
HeLa Cells
Humans
Photochemical Processes
Physical Sciences
Plasmids
Science & Technology
Ultraviolet Rays
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Summary:A new method for site-specific caging of plasmid DNA was developed to enable light-activation of gene expression in living cells by exposure to a low dose of light.
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ISSN:1359-7345
1364-548X
DOI:10.1039/b922502a