THE DEGRADATION AND BIOCOMPATIBILITY OF WATERBORNE BIODEGRADABLE POLYURETHANES FOR TISSUE ENGINEERING

To better investigate the degradation and biocompatibility of waterborne biodegradable polyurethanes for tissue engineering, a series of new waterborne biodegradable polyurethanes （PEGPUs） with low degree of crosslinking was synthesized using IPDI, BDO and L-lysine as hard segments, PCL and PEG as s...

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Bibliographic Details
Published inChinese journal of polymer science Vol. 31; no. 10; pp. 1451 - 1462
Main Authors Song, Ni-jia, Jiang, Xia, Li, Jie-hua, Pang, Yong, Li, Jian-shu, Tan, Hong, Fu, Qiang
Format Journal Article
LanguageEnglish
Published Berlin/Heidelberg Springer Berlin Heidelberg 01.10.2013
Subjects
Characterization and Evaluation of Materials
Chemistry
Chemistry and Materials Science
Condensed Matter Physics
Industrial Chemistry/Chemical Engineering
Polymer Sciences
傅里叶变换红外光谱
可生物降解
水性
生物相容性
磷酸盐缓冲溶液
组织工程
聚氨基甲酸乙酯
聚氨酯
Degradation
Cytotoxicity
Waterborne biodegradable polyurethane
Structure
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Summary:To better investigate the degradation and biocompatibility of waterborne biodegradable polyurethanes for tissue engineering, a series of new waterborne biodegradable polyurethanes （PEGPUs） with low degree of crosslinking was synthesized using IPDI, BDO and L-lysine as hard segments, PCL and PEG as soft segment. The bulk structures and properties of the prepared polyurethanes were characterized by Fourier transform infrared spectroscopy （FTIR）, differential scanning calorimetry （DSC）, tensile mechanical tests and water contact angle （WCA） measurements. The degree of microphase separation was slightly improved because of the lowered crosslinking degree of these PEGPUs in comparison with the high cross-linking degree samples, leading to good mechanical properties, as indicated by DSC and stress-strain data. Moreover, biodegradability of the polyurethanes was evaluated in phosphate buffer solutions （PBS） under different pH values and enzymatic solution at pH 7.4 through weight loss monitoring. The results suggested that the degradation of these PEGPUs was closely related to their bulk and surface properties. And the degradation products didn＇t show apparent inhibition effect against fibroblasts in vitro. These studies demonstrated that the waterborne biodegradable polyurethanes could find potential use in soft tissue engineering and tissue regeneration.
Bibliography:To better investigate the degradation and biocompatibility of waterborne biodegradable polyurethanes for tissue engineering, a series of new waterborne biodegradable polyurethanes （PEGPUs） with low degree of crosslinking was synthesized using IPDI, BDO and L-lysine as hard segments, PCL and PEG as soft segment. The bulk structures and properties of the prepared polyurethanes were characterized by Fourier transform infrared spectroscopy （FTIR）, differential scanning calorimetry （DSC）, tensile mechanical tests and water contact angle （WCA） measurements. The degree of microphase separation was slightly improved because of the lowered crosslinking degree of these PEGPUs in comparison with the high cross-linking degree samples, leading to good mechanical properties, as indicated by DSC and stress-strain data. Moreover, biodegradability of the polyurethanes was evaluated in phosphate buffer solutions （PBS） under different pH values and enzymatic solution at pH 7.4 through weight loss monitoring. The results suggested that the degradation of these PEGPUs was closely related to their bulk and surface properties. And the degradation products didn＇t show apparent inhibition effect against fibroblasts in vitro. These studies demonstrated that the waterborne biodegradable polyurethanes could find potential use in soft tissue engineering and tissue regeneration.
Waterborne biodegradable polyurethane; Structure; Degradation; Cytotoxicity.
11-2015/O6
ISSN:0256-7679
1439-6203
DOI:10.1007/s10118-013-1315-7