Ratiometric analysis of reversible thia-Michael reactions using nitrile-tagged molecules by Raman microscopy

Ratiometric Raman analysis of reversible thia-Michael reactions was achieved using α-cyanoacrylic acid (αCNA) derivatives. Among αCNAs, the smallest derivative, ThioRas (molecular weight: 167 g mol −1 ), and its glutathione adduct were simultaneously detected in various subcellular locations using R...

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Published inChemical communications (Cambridge, England) Vol. 59; no. 98; pp. 14563 - 14566
Main Authors Yamakoshi, Hiroyuki, Shibata, Daiki, Bando, Kazuki, Kajimoto, Shinji, Kohyama, Aki, Egoshi, Syusuke, Dodo, Kosuke, Iwabuchi, Yoshiharu, Sodeoka, Mikiko, Fujita, Katsumasa, Nakabayashi, Takakazu
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 07.12.2023
Royal Society of Chemistry
Subjects
Chemistry
Chemistry, Multidisciplinary
Glutathione
Microscopy
Physical Sciences
Raman spectroscopy
Science & Technology
THIOLS
PROBES
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Summary:Ratiometric Raman analysis of reversible thia-Michael reactions was achieved using α-cyanoacrylic acid (αCNA) derivatives. Among αCNAs, the smallest derivative, ThioRas (molecular weight: 167 g mol −1 ), and its glutathione adduct were simultaneously detected in various subcellular locations using Raman microscopy. Ratiometric Raman analysis of reversible thia-Michael reactions was achieved using α-cyanoacrylic acid (αCNA) derivatives.
Bibliography:Electronic supplementary information (ESI) available. See DOI
https://doi.org/10.1039/d3cc05015g
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1359-7345
1364-548X
DOI:10.1039/d3cc05015g