Erythrocyte plasma membrane redox system in first degree relatives of type 2 diabetic patients

Abstract Diabetes mellitus (TDM) is strongly associated with oxidative stress. Human erythrocytes contain a plasma membrane redox system (PMRS) which transfers electrons from intracellular donors (NADH, ascorbate) to extracellular acceptors outside the cell. We show that the activity of erythrocyte...

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Bibliographic Details
Published inInternational Journal of Diabetes Mellitus Vol. 2; no. 2; pp. 119 - 121
Main Authors Rizvi, Syed Ibrahim, Srivastava, Neeti
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 01.08.2010
Subjects
AFR reductase
Diabetes
Endocrinology & Metabolism
Erythrocyte
Internal Medicine
Oxidative stress
PMRS
Erythrocyte
Oxidative stress
Diabetes
PMRS
AFR reductase
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Summary:Abstract Diabetes mellitus (TDM) is strongly associated with oxidative stress. Human erythrocytes contain a plasma membrane redox system (PMRS) which transfers electrons from intracellular donors (NADH, ascorbate) to extracellular acceptors outside the cell. We show that the activity of erythrocyte PMRS and AFR reductase becomes elevated in first degree relatives of type 2 diabetics and in TDM subjects. The increase in PMRS and AFR reductase signifies compensatory mechanisms to mitigate increased oxidative stress. These findings show that an impaired redox balance may be a cause the disturbance of homeostasis in type 2 diabetic families, even before the development of the disease.
ISSN:1877-5934
DOI:10.1016/j.ijdm.2010.05.005