Epidemiological features and dynamic changes in blood biochemical indices for COVID-19 patients in Hebi
Millions of people have died of coronavirus disease 2019 (COVID-19) due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, and retrospective studies of the disease in local regions are necessary. To characterize the epidemiological features and dynamic changes in blood bioche...
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Published in | World journal of clinical cases Vol. 10; no. 8; pp. 2404 - 2419 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Baishideng Publishing Group Inc
16.03.2022
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Subjects | |
Online Access | Get full text |
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Summary: | Millions of people have died of coronavirus disease 2019 (COVID-19) due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, and retrospective studies of the disease in local regions are necessary.
To characterize the epidemiological features and dynamic changes in blood biochemical indices for SARS-CoV-2-infected patients in Hebi, a representative city with a large floating population in North China.
From January 25 to February 10, 2020, the clinical data of patients who tested positive for SARS-CoV-2 by quantitative real-time polymerase chain reaction in Hebi city (China) were evaluated at admission, and laboratory data for hematologic parameters, inflammatory indices, coagulation function indices, liver function indices, blood lipid indices, renal function indices, myocardial enzyme activities and five blood biochemical markers of immunity were evaluated at admission, upon hospitalization and before discharge.
Sixteen confirmed COVID-19 patients developed pneumonia but were cured after adequate treatment. Fever and fatigue were the common symptoms. The most common laboratory abnormalities of patients at admission were leukopenia, eosinopenia, decreased percentage of eosinophils, elevated high sensitivity C-reactive protein and fibrinogen levels, hypoalbuminemia, mildly increased aspartate transferase activity and levels of bilirubin, and increased levels of β2-microglobulin. Importantly, aggravated liver dysfunction was detected in most patients, which may be partially attributed to virus infection as well as medicinal treatment.
This study provides several potential diagnostic markers and dynamic biochemical indices of disease progression to better prevent, diagnose and treat COVID-19 infection. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Corresponding author: Rui-Fang Hou, Doctor, MD, Chairman, Doctor, Department of Infectious Diseases, The People’s Hospital of Hebi, Henan University, Hebi Key Laboratory of Liver Disease, Jiuzhou Street, Qibin District, Hebi 458031, Henan Province, China. dr_rfhou@126.com Author contributions: Nie XB and Hou RF designed the research study; Shi BS, Zhang L, Niu WL, Xue T, Li LQ and Wei XY performed the research; Wang YD and Chen WD contributed analytic tools; Nie XB analyzed the data and wrote the manuscript; Hou RF revised the manuscript; And all authors have read and approve the final manuscript. |
ISSN: | 2307-8960 2307-8960 |
DOI: | 10.12998/wjcc.v10.i8.2404 |