Comparison of Kinetic Curve between Gadodiamide Hydrate and Gadobutrol on Breast Dynamic Contrast-enhanced Magnetic Resonance Imaging in Invasive Ductal Carcinoma

• Published in: Japanese Journal of Radiological Technology Vol. 74; no. 11; pp. 1313 - 1318
• Main Authors: Koori, Norikazu, Kurata, Kazuma, Nihashi, Takashi, Noda, Sumiyo, Mashita, Yuuko
• Format: Journal Article
• Language: English; Japanese
• Published: Japan Japanese Society of Radiological Technology 2018; Japan Science and Technology Agency
• Subjects: BI-RADS; breast magnetic resonance imaging; Breast Neoplasms - diagnostic imaging; Carcinoma, Ductal - diagnostic imaging; Contrast agents; Contrast Media - administration & dosage; Diagnosis; Diagnostic systems; Female; gadobutrol; Gadolinium DTPA - administration & dosage; Humans; Image contrast; Image processing; Invasiveness; kinetic curve; Magnetic Resonance Imaging; Medical imaging; NMR; Nuclear magnetic resonance; Organometallic Compounds - administration & dosage; Resonance; time intensity curve; breast magnetic resonance imaging; BI-RADS; kinetic curve; gadobutrol; time intensity curve
• ISSN: 0369-4305; 1881-4883
• DOI: 10.6009/jjrt.2018_JSRT_74.11.1313

The shape of the kinetic curve for gadobutrol is reportedly different compared with that for other conventional contrast agents. We speculate that the shape of gadobutrol kinetic curve may be influenced by different magnetic resonance imaging (MRI) protocols and evaluation methods. The purpose of our study was to assess the influence between gadobutrol and other conventional contrast agent (gadodiamide hydrate) on the kinetic curve in invasive ductal carcinoma (IDC). We assessed 139 women of IDC in this study. Gadodiamide hydrate (2 ml/s) was administered to 69 women, and gadobutrol (1 ml/s) was administrated to 70 women, both contrast agents at 0.1 mmol/kg BW. When the kinetic curves of contrast agents were evaluated between by Breast Imaging Reporting and Data System (BI-RADS) 4th edition and BI-RADS 5th edition, suggested that the analysis method of BI-RADS may affect. Patient group who were administered gadobutrol demonstrated a lower washout rate when compared with patient group who were administered gadodiamide hydrate administration (P<0.01). These results suggest that the kinetic curve characteristics of gadobutrol are an important consideration in diagnosis. Therefore, it is necessary to perform image diagnosis by considering the influence of the contrast agent and the analysis method, when image diagnostic doctor perform image diagnosis.