Increased turnover of very low density lipoprotein triglyceride during treatment with cholestyramine in familial hypercholesterolaemia

Kinetics of very low density lipoprotein (VLDL) triglyceride were determined in seven patients with heterozygous familial hypercholesterolaemia, using a 3H-glycerol technique. The study was repeated after 5-7 weeks of therapy with the bile acid-binding resin, cholestyramine. The rate of synthesis of...

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Bibliographic Details
Published inJournal of internal medicine Vol. 227; no. 3; p. 201
Main Authors Angelin, B, Leijd, B, Hultcrantz, R, Einarsson, K
Format Journal Article
LanguageEnglish
Published England 01.03.1990
Subjects
Adult
Cholestyramine Resin - therapeutic use
Female
Heterozygote
Humans
Hyperlipoproteinemia Type II - blood
Hyperlipoproteinemia Type II - drug therapy
Lipoproteins, VLDL - metabolism
Male
Middle Aged
Particle Size
Time Factors
Triglycerides - metabolism
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Summary:Kinetics of very low density lipoprotein (VLDL) triglyceride were determined in seven patients with heterozygous familial hypercholesterolaemia, using a 3H-glycerol technique. The study was repeated after 5-7 weeks of therapy with the bile acid-binding resin, cholestyramine. The rate of synthesis of VLDL triglyceride was increased by 85% (P less than 0.05) during resin therapy. Simultaneously, the fractional catabolic rate of VLDL was increased by 40% (P less than 0.02), so that only a moderate increase in plasma concentration was observed. Repeated measurements of VLDL size by electron microscopy (before, 1 week, and 5-7 weeks after initiation of therapy) indicated that a transient increase in VLDL size occurred in response to cholestyramine. The results are consistent with a stimulatory effect of bile acid sequestrants on VLDL triglyceride production and indicate that, in most subjects, a compensatory increase in VLDL triglyceride removal occurs.
ISSN:0954-6820
DOI:10.1111/j.1365-2796.1990.tb00143.x